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- W3033982016 abstract "Abstract Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centromere-specific histone dCENP-A in M/G1 phase, which depends on the eviction of previously deposited H3/H3.3-placeholder nucleosomes. Here we demonstrate that the histone chaperone and transcription elongation factor Spt6 spatially and temporarily coincides with centromeric transcription and prevents the loss of old CENP-A nucleosomes in both Drosophila and human cells. Spt6 binds directly to dCENP-A and dCENP-A mutants carrying phosphomimetic residues alleviate this association. Retention of phosphomimetic dCENP-A mutants is reduced relative to wildtype, while non-phosphorylatable dCENP-A retention is increased and accumulates at the centromere. We conclude that Spt6 acts as a conserved CENP-A maintenance factor that ensures long-term stability of epigenetic centromere identity during transcription-mediated chromatin remodeling." @default.
- W3033982016 created "2020-06-12" @default.
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- W3033982016 date "2020-06-10" @default.
- W3033982016 modified "2023-10-16" @default.
- W3033982016 title "Spt6 is a maintenance factor for centromeric CENP-A" @default.
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- W3033982016 doi "https://doi.org/10.1038/s41467-020-16695-7" @default.
- W3033982016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7287101" @default.
- W3033982016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32522980" @default.
- W3033982016 hasPublicationYear "2020" @default.
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