Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033991307> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3033991307 endingPage "795" @default.
- W3033991307 startingPage "787" @default.
- W3033991307 abstract "Around the world, emergence and re-emergence of Dengue Virus (DENV) are one of the serious public health concerns. The infection of DENV to human population is mainly caused by the bite of an Aedes mosquito. In an estimate, it is found that annually around 100–125 million new dengue incidences are reported from approximately 120 endemic countries. The lone licensed dengue vaccine was not effective to prevent the disease globally. Many dengue vaccines are under clinical trial but there are concerns about the trial reports on safety and efficacy of vaccine. In these circumstances, an epitope-based peptide vaccine is expected to be safe and efficacious against dengue. In this study, the computational prediction of T cell epitope-based peptide vaccine for dengue virus strain BR/97-111 Envelop protein is performed. Total 28 CTL epitopes were predicted using NetCTL 1.2 server. Out of these, five were found to possess antigenicity through VaxiJen 2.0. Further, toxicity prediction using ToxinPred and their conservancy prediction resulted in three epitopes, i.e. TSEIQLTDY, IGIGILLTW and IAVGMVTLY epitope peptide. All these were physically docked and studied for molecular dynamics simulation. In-depth analysis of these results suggests that the predicted three epitopes could be used as a potent vaccine candidate against global dengue disease challenges, although an experimental validation is required for final confirmation." @default.
- W3033991307 created "2020-06-12" @default.
- W3033991307 creator A5000116814 @default.
- W3033991307 creator A5029181413 @default.
- W3033991307 creator A5082030725 @default.
- W3033991307 date "2020-06-03" @default.
- W3033991307 modified "2023-10-02" @default.
- W3033991307 title "T cell epitope designing for dengue peptide vaccine using docking and molecular simulation studies" @default.
- W3033991307 cites W1599693279 @default.
- W3033991307 cites W1896254721 @default.
- W3033991307 cites W1925429148 @default.
- W3033991307 cites W1970966156 @default.
- W3033991307 cites W1973980688 @default.
- W3033991307 cites W2012625502 @default.
- W3033991307 cites W2014274241 @default.
- W3033991307 cites W2024023167 @default.
- W3033991307 cites W2024874218 @default.
- W3033991307 cites W2042493200 @default.
- W3033991307 cites W2061543974 @default.
- W3033991307 cites W2099094631 @default.
- W3033991307 cites W2102367710 @default.
- W3033991307 cites W2117333383 @default.
- W3033991307 cites W2118441980 @default.
- W3033991307 cites W2131222241 @default.
- W3033991307 cites W2142371145 @default.
- W3033991307 cites W2143397050 @default.
- W3033991307 cites W2151460035 @default.
- W3033991307 cites W2155786171 @default.
- W3033991307 cites W2296204072 @default.
- W3033991307 cites W2323889349 @default.
- W3033991307 cites W2794234984 @default.
- W3033991307 cites W2907056575 @default.
- W3033991307 doi "https://doi.org/10.1080/08927022.2020.1772970" @default.
- W3033991307 hasPublicationYear "2020" @default.
- W3033991307 type Work @default.
- W3033991307 sameAs 3033991307 @default.
- W3033991307 citedByCount "19" @default.
- W3033991307 countsByYear W30339913072020 @default.
- W3033991307 countsByYear W30339913072021 @default.
- W3033991307 countsByYear W30339913072022 @default.
- W3033991307 countsByYear W30339913072023 @default.
- W3033991307 crossrefType "journal-article" @default.
- W3033991307 hasAuthorship W3033991307A5000116814 @default.
- W3033991307 hasAuthorship W3033991307A5029181413 @default.
- W3033991307 hasAuthorship W3033991307A5082030725 @default.
- W3033991307 hasConcept C159047783 @default.
- W3033991307 hasConcept C159654299 @default.
- W3033991307 hasConcept C195616568 @default.
- W3033991307 hasConcept C203014093 @default.
- W3033991307 hasConcept C2776789287 @default.
- W3033991307 hasConcept C2779026604 @default.
- W3033991307 hasConcept C2779308166 @default.
- W3033991307 hasConcept C2779635636 @default.
- W3033991307 hasConcept C533803919 @default.
- W3033991307 hasConcept C86803240 @default.
- W3033991307 hasConceptScore W3033991307C159047783 @default.
- W3033991307 hasConceptScore W3033991307C159654299 @default.
- W3033991307 hasConceptScore W3033991307C195616568 @default.
- W3033991307 hasConceptScore W3033991307C203014093 @default.
- W3033991307 hasConceptScore W3033991307C2776789287 @default.
- W3033991307 hasConceptScore W3033991307C2779026604 @default.
- W3033991307 hasConceptScore W3033991307C2779308166 @default.
- W3033991307 hasConceptScore W3033991307C2779635636 @default.
- W3033991307 hasConceptScore W3033991307C533803919 @default.
- W3033991307 hasConceptScore W3033991307C86803240 @default.
- W3033991307 hasIssue "10" @default.
- W3033991307 hasLocation W30339913071 @default.
- W3033991307 hasOpenAccess W3033991307 @default.
- W3033991307 hasPrimaryLocation W30339913071 @default.
- W3033991307 hasRelatedWork W2056019569 @default.
- W3033991307 hasRelatedWork W2168704739 @default.
- W3033991307 hasRelatedWork W2186465316 @default.
- W3033991307 hasRelatedWork W2466853895 @default.
- W3033991307 hasRelatedWork W3003968373 @default.
- W3033991307 hasRelatedWork W3019547263 @default.
- W3033991307 hasRelatedWork W3033991307 @default.
- W3033991307 hasRelatedWork W3102957462 @default.
- W3033991307 hasRelatedWork W4283219270 @default.
- W3033991307 hasRelatedWork W3099043951 @default.
- W3033991307 hasVolume "46" @default.
- W3033991307 isParatext "false" @default.
- W3033991307 isRetracted "false" @default.
- W3033991307 magId "3033991307" @default.
- W3033991307 workType "article" @default.