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• W3033994554 endingPage "477" @default.
• W3033994554 startingPage "477" @default.
• W3033994554 abstract "Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculiar susceptibility of newborns to oxidative stress supports the prophylactic use of melatonin in preventing or decreasing oxidative stress-mediated diseases. Melatonin, an effective direct free-radical scavenger, easily diffuses through biological membranes and exerts pleiotropic activity everywhere. Multiple investigations have assessed the effectiveness of melatonin to reduce the “oxygen radical diseases of newborn” including perinatal brain injury, sepsis, chronic lung disease (CLD), and necrotizing enterocolitis (NEC). Further studies are still awaited to test melatonin activity during perinatal period." @default.
• W3033994554 created "2020-06-12" @default.
• W3033994554 creator A5025395065 @default.
• W3033994554 creator A5037248904 @default.
• W3033994554 creator A5046806442 @default.
• W3033994554 creator A5063159500 @default.
• W3033994554 date "2020-06-02" @default.
• W3033994554 modified "2023-10-18" @default.
• W3033994554 title "Use of Melatonin in Oxidative Stress Related Neonatal Diseases" @default.
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• W3033994554 doi "https://doi.org/10.3390/antiox9060477" @default.

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