FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033994597> ?p ?o ?g. }

• W3033994597 abstract "Abstract Many patients with ER+ HER2− primary breast cancer are being deferred from surgery to neoadjuvant endocrine therapy (NeoET) during the COVID-19 pandemic. We have collated data from multiple international trials of presurgical endocrine therapy in order to provide guidance on the identification of patients who may have insufficiently endocrine-sensitive tumors and should be prioritised for early surgery or neoadjuvant chemotherapy rather than NeoET during or in the aftermath of the COVID-19 pandemic for safety or when surgical activity needs to be prioritized. For postmenopausal patients, our data provide strong support for the use of ER and PgR status at diagnosis for triaging of patients into three groups in which (taking into account clinical factors): (i) NeoET is likely to be inappropriate (Allred ER <6 or ER 6 and PgR <6) (ii) a biopsy for Ki67 analysis (on-treatment Ki67) could be considered after 2–4 weeks of NeoET (a: ER 7 or 8 and PgR <6 or b: ER 6 or 7 and PgR ≥6) or (iii) NeoET is an acceptable course of action (ER 8 and PgR ≥6). Cut-offs for percentage of cells positive are also given. For group (ii), a high early on-treatment level of Ki67 (>10%) indicates a higher priority for early surgery. Too few data were available for premenopausal patients to provide a similar treatment algorithm. These guidelines should be helpful for managing patients with early ER+ HER2− breast cancer during and in the aftermath of the COVID-19 crisis." @default.
• W3033994597 created "2020-06-12" @default.
• W3033994597 creator A5006665510 @default.
• W3033994597 creator A5009199118 @default.
• W3033994597 creator A5012681752 @default.
• W3033994597 creator A5014363979 @default.
• W3033994597 creator A5016623639 @default.
• W3033994597 creator A5022444628 @default.
• W3033994597 creator A5027231412 @default.
• W3033994597 creator A5031138706 @default.
• W3033994597 creator A5031915637 @default.
• W3033994597 creator A5035383163 @default.
• W3033994597 creator A5040008219 @default.
• W3033994597 creator A5044665296 @default.
• W3033994597 creator A5048450614 @default.
• W3033994597 creator A5049175137 @default.
• W3033994597 creator A5054650117 @default.
• W3033994597 creator A5057135409 @default.
• W3033994597 creator A5057689412 @default.
• W3033994597 creator A5073889721 @default.
• W3033994597 creator A5082661564 @default.
• W3033994597 date "2020-06-08" @default.
• W3033994597 modified "2023-10-17" @default.
• W3033994597 title "Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic" @default.
• W3033994597 cites W2009551388 @default.
• W3033994597 cites W2044702943 @default.
• W3033994597 cites W2052185376 @default.
• W3033994597 cites W2062071674 @default.
• W3033994597 cites W2109916911 @default.
• W3033994597 cites W2111253826 @default.
• W3033994597 cites W2113435829 @default.
• W3033994597 cites W2117251248 @default.
• W3033994597 cites W2118728607 @default.
• W3033994597 cites W2130594114 @default.
• W3033994597 cites W2136034662 @default.
• W3033994597 cites W2144535237 @default.
• W3033994597 cites W2150134401 @default.
• W3033994597 cites W2164461552 @default.
• W3033994597 cites W2407306171 @default.
• W3033994597 cites W2574190322 @default.
• W3033994597 cites W2592394732 @default.
• W3033994597 cites W2902672529 @default.
• W3033994597 cites W3018098307 @default.
• W3033994597 cites W3019205311 @default.
• W3033994597 cites W3028918158 @default.
• W3033994597 cites W3033994597 @default.
• W3033994597 doi "https://doi.org/10.1038/s41523-020-0168-9" @default.
• W3033994597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7280290" @default.
• W3033994597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33579939" @default.
• W3033994597 hasPublicationYear "2020" @default.
• W3033994597 type Work @default.
• W3033994597 sameAs 3033994597 @default.
• W3033994597 citedByCount "40" @default.
• W3033994597 countsByYear W30339945972020 @default.
• W3033994597 countsByYear W30339945972021 @default.
• W3033994597 countsByYear W30339945972022 @default.
• W3033994597 countsByYear W30339945972023 @default.
• W3033994597 crossrefType "journal-article" @default.
• W3033994597 hasAuthorship W3033994597A5006665510 @default.
• W3033994597 hasAuthorship W3033994597A5009199118 @default.
• W3033994597 hasAuthorship W3033994597A5012681752 @default.
• W3033994597 hasAuthorship W3033994597A5014363979 @default.
• W3033994597 hasAuthorship W3033994597A5016623639 @default.
• W3033994597 hasAuthorship W3033994597A5022444628 @default.
• W3033994597 hasAuthorship W3033994597A5027231412 @default.
• W3033994597 hasAuthorship W3033994597A5031138706 @default.
• W3033994597 hasAuthorship W3033994597A5031915637 @default.
• W3033994597 hasAuthorship W3033994597A5035383163 @default.
• W3033994597 hasAuthorship W3033994597A5040008219 @default.
• W3033994597 hasAuthorship W3033994597A5044665296 @default.
• W3033994597 hasAuthorship W3033994597A5048450614 @default.
• W3033994597 hasAuthorship W3033994597A5049175137 @default.
• W3033994597 hasAuthorship W3033994597A5054650117 @default.
• W3033994597 hasAuthorship W3033994597A5057135409 @default.
• W3033994597 hasAuthorship W3033994597A5057689412 @default.
• W3033994597 hasAuthorship W3033994597A5073889721 @default.
• W3033994597 hasAuthorship W3033994597A5082661564 @default.
• W3033994597 hasBestOaLocation W30339945971 @default.
• W3033994597 hasConcept C121608353 @default.
• W3033994597 hasConcept C126322002 @default.
• W3033994597 hasConcept C143998085 @default.
• W3033994597 hasConcept C2776694085 @default.
• W3033994597 hasConcept C2778292576 @default.
• W3033994597 hasConcept C2779134260 @default.
• W3033994597 hasConcept C29456083 @default.
• W3033994597 hasConcept C3008058167 @default.
• W3033994597 hasConcept C46699223 @default.
• W3033994597 hasConcept C524204448 @default.
• W3033994597 hasConcept C530470458 @default.
• W3033994597 hasConcept C535046627 @default.
• W3033994597 hasConcept C61434518 @default.
• W3033994597 hasConcept C71315377 @default.
• W3033994597 hasConcept C71924100 @default.
• W3033994597 hasConcept C89623803 @default.
• W3033994597 hasConceptScore W3033994597C121608353 @default.
• W3033994597 hasConceptScore W3033994597C126322002 @default.
• W3033994597 hasConceptScore W3033994597C143998085 @default.
• W3033994597 hasConceptScore W3033994597C2776694085 @default.
• W3033994597 hasConceptScore W3033994597C2778292576 @default.
• W3033994597 hasConceptScore W3033994597C2779134260 @default.

• next