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- W3033996966 endingPage "1402" @default.
- W3033996966 startingPage "1402" @default.
- W3033996966 abstract "Ovarian cancer is the most lethal gynecological malignancy due to its late detection and high recurrence rate. Resistance to conventional platinum-based therapies and metastasis are attributed to a population of cells within tumors called cancer stem cells, which possess stem-like features and are able to recapitulate new tumors. Recent studies have deepened the understanding of the biology of ovarian cancer stem cells and their special properties and have identified multiple markers and signaling pathways responsible for their self-renewal abilities. Targeting cancer stem cells represents the most promising strategy for overcoming therapy resistance and reducing mortality in ovarian cancer, but further efforts must be made to improve our understanding of the mechanisms involved in therapy resistance. In this review, we summarize our current knowledge about ovarian cancer stem cells, their involvement in metastasis and their interactions with the tumor microenvironment; we also discuss the therapeutic approaches that are being developed to target them to prevent tumor relapse." @default.
- W3033996966 created "2020-06-12" @default.
- W3033996966 creator A5017542401 @default.
- W3033996966 creator A5063985660 @default.
- W3033996966 date "2020-06-04" @default.
- W3033996966 modified "2023-10-15" @default.
- W3033996966 title "Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer" @default.
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