Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034004098> ?p ?o ?g. }
- W3034004098 abstract "Abstract The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades leading to assembly of two SPK scaffolds and recruitment of diverse effectors in Neurospora crassa . Both scaffolds are transported to the SPK by the myosin V motor (MYO-5), with the coiled-coil protein SPZ-1 acting as cargo adaptor. Neither scaffold appears to be required for accumulation of SPK secretory vesicles. One scaffold consists of Leashin-2 (LAH-2), which is required for SPK localization of the signalling kinase COT-1 and the glycolysis enzyme GPI-1. The other scaffold comprises a complex of Janus-1 (JNS-1) and the polarisome protein SPA-2. Via its Spa homology domain (SHD), SPA-2 recruits a calponin domain-containing F-actin effector (CCP-1). The SHD NMR structure reveals a conserved surface groove required for effector binding. Similarities between SPA-2/JNS-1 and the metazoan GIT/PIX complex identify foundational features of the cell polarity apparatus that predate the fungal-metazoan divergence." @default.
- W3034004098 created "2020-06-12" @default.
- W3034004098 creator A5002059933 @default.
- W3034004098 creator A5020836415 @default.
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- W3034004098 creator A5050256110 @default.
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- W3034004098 creator A5068889291 @default.
- W3034004098 creator A5076471461 @default.
- W3034004098 creator A5089461995 @default.
- W3034004098 date "2020-06-05" @default.
- W3034004098 modified "2023-09-27" @default.
- W3034004098 title "Spitzenkörper assembly mechanisms reveal conserved features of fungal and metazoan polarity scaffolds" @default.
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