Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034015262> ?p ?o ?g. }
- W3034015262 abstract "ABSTRACT Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. The mechanisms by which 17α-estradiol elicits these benefits remain unresolved. Herein, we show that 17α-estradiol elicits similar genomic binding and transcriptional activation through estrogen receptor α (ERα) to that of 17β-estradiol. In addition, we show that the ablation of ERα completely attenuates the beneficial metabolic effects of 17α-E2 in male mice. Our findings suggest that 17α-E2 acts primarily through the liver and hypothalamus to improve metabolic parameters in male mice. Lastly, we also determined that 17α-E2 improves metabolic parameters in male rats, thereby proving that the beneficial effects of 17α-E2 are not limited to mice. Collectively, these studies suggest ERα may be a drug target for mitigating chronic diseases in male mammals." @default.
- W3034015262 created "2020-06-12" @default.
- W3034015262 creator A5004804964 @default.
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- W3034015262 creator A5086984121 @default.
- W3034015262 date "2020-06-03" @default.
- W3034015262 modified "2023-09-23" @default.
- W3034015262 title "Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α" @default.
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