Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034023904> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3034023904 endingPage "500" @default.
- W3034023904 startingPage "492" @default.
- W3034023904 abstract "Abstract Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are critical processes that are involved in atherosclerosis. The aim of this study was to explore the role of microRNA-491-5p (miR-491-5p) in the progression of atherosclerosis by regulating the growth and migration of VSMCs. In this study, we showed that the expression of miR-491-5p was downregulated in the atherosclerotic plaque tissues and plasma samples of the patients with atherosclerosis. The bioinformatic analysis and dual-luciferase reporter assay identified that matrix metallopeptidase-9 (MMP-9) was a target gene of miR-491-5p. The results showed a significant upregulation of MMP-9 in the atherosclerotic plaque tissues and plasma samples. Subsequently, the results also showed that downregulation of miR-491-5p significantly promoted the proliferation and migration of VSMCs and inhibited the apoptosis in VSMCs. Furthermore, we detected the effects of miR-491-5p mimic on the growth and migration of VSMCs, and the results illustrated that miR-491-5p mimic could inhibit the proliferation and migration of VSMCs and promote the apoptosis of VSMCs. Notably, MMP-9 plasmid could reverse all the effects of miR-491-5p mimic on VSMCs. Collectively, our study provides the first evidence that miR-491-5p inhibited the growth and migration of VSMCs by targeting MMP-9, which might provide new biomarkers and potential therapeutic targets for atherosclerosis treatment." @default.
- W3034023904 created "2020-06-12" @default.
- W3034023904 creator A5027270160 @default.
- W3034023904 creator A5050466653 @default.
- W3034023904 creator A5081065929 @default.
- W3034023904 creator A5087327189 @default.
- W3034023904 date "2020-01-01" @default.
- W3034023904 modified "2023-10-16" @default.
- W3034023904 title "microRNA-491-5p protects against atherosclerosis by targeting matrix metallopeptidase-9" @default.
- W3034023904 cites W1966533061 @default.
- W3034023904 cites W1981348086 @default.
- W3034023904 cites W1985335791 @default.
- W3034023904 cites W1997080475 @default.
- W3034023904 cites W2007827714 @default.
- W3034023904 cites W2014898037 @default.
- W3034023904 cites W2107277218 @default.
- W3034023904 cites W2139883861 @default.
- W3034023904 cites W2269676560 @default.
- W3034023904 cites W2274924551 @default.
- W3034023904 cites W2523222374 @default.
- W3034023904 cites W2594848225 @default.
- W3034023904 cites W2752590665 @default.
- W3034023904 cites W278692179 @default.
- W3034023904 cites W2794678703 @default.
- W3034023904 cites W2797166244 @default.
- W3034023904 cites W2803608485 @default.
- W3034023904 cites W2851773305 @default.
- W3034023904 cites W2889322279 @default.
- W3034023904 cites W2894603924 @default.
- W3034023904 cites W2896307300 @default.
- W3034023904 cites W2927082434 @default.
- W3034023904 cites W2956026925 @default.
- W3034023904 doi "https://doi.org/10.1515/med-2020-0047" @default.
- W3034023904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7706122" @default.
- W3034023904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33313408" @default.
- W3034023904 hasPublicationYear "2020" @default.
- W3034023904 type Work @default.
- W3034023904 sameAs 3034023904 @default.
- W3034023904 citedByCount "6" @default.
- W3034023904 countsByYear W30340239042021 @default.
- W3034023904 countsByYear W30340239042022 @default.
- W3034023904 countsByYear W30340239042023 @default.
- W3034023904 crossrefType "journal-article" @default.
- W3034023904 hasAuthorship W3034023904A5027270160 @default.
- W3034023904 hasAuthorship W3034023904A5050466653 @default.
- W3034023904 hasAuthorship W3034023904A5081065929 @default.
- W3034023904 hasAuthorship W3034023904A5087327189 @default.
- W3034023904 hasBestOaLocation W30340239041 @default.
- W3034023904 hasConcept C104317684 @default.
- W3034023904 hasConcept C109523444 @default.
- W3034023904 hasConcept C126322002 @default.
- W3034023904 hasConcept C127561419 @default.
- W3034023904 hasConcept C145059251 @default.
- W3034023904 hasConcept C190283241 @default.
- W3034023904 hasConcept C2779395532 @default.
- W3034023904 hasConcept C2992686903 @default.
- W3034023904 hasConcept C502942594 @default.
- W3034023904 hasConcept C55493867 @default.
- W3034023904 hasConcept C71924100 @default.
- W3034023904 hasConcept C86803240 @default.
- W3034023904 hasConcept C95444343 @default.
- W3034023904 hasConceptScore W3034023904C104317684 @default.
- W3034023904 hasConceptScore W3034023904C109523444 @default.
- W3034023904 hasConceptScore W3034023904C126322002 @default.
- W3034023904 hasConceptScore W3034023904C127561419 @default.
- W3034023904 hasConceptScore W3034023904C145059251 @default.
- W3034023904 hasConceptScore W3034023904C190283241 @default.
- W3034023904 hasConceptScore W3034023904C2779395532 @default.
- W3034023904 hasConceptScore W3034023904C2992686903 @default.
- W3034023904 hasConceptScore W3034023904C502942594 @default.
- W3034023904 hasConceptScore W3034023904C55493867 @default.
- W3034023904 hasConceptScore W3034023904C71924100 @default.
- W3034023904 hasConceptScore W3034023904C86803240 @default.
- W3034023904 hasConceptScore W3034023904C95444343 @default.
- W3034023904 hasIssue "1" @default.
- W3034023904 hasLocation W30340239041 @default.
- W3034023904 hasLocation W30340239042 @default.
- W3034023904 hasOpenAccess W3034023904 @default.
- W3034023904 hasPrimaryLocation W30340239041 @default.
- W3034023904 hasRelatedWork W2065289988 @default.
- W3034023904 hasRelatedWork W2093977802 @default.
- W3034023904 hasRelatedWork W2208888561 @default.
- W3034023904 hasRelatedWork W2379086703 @default.
- W3034023904 hasRelatedWork W2389010414 @default.
- W3034023904 hasRelatedWork W2466886203 @default.
- W3034023904 hasRelatedWork W2573992804 @default.
- W3034023904 hasRelatedWork W2781823908 @default.
- W3034023904 hasRelatedWork W3033389342 @default.
- W3034023904 hasRelatedWork W3150490778 @default.
- W3034023904 hasVolume "15" @default.
- W3034023904 isParatext "false" @default.
- W3034023904 isRetracted "false" @default.
- W3034023904 magId "3034023904" @default.
- W3034023904 workType "article" @default.