FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034025107> ?p ?o ?g. }

• W3034025107 endingPage "2261" @default.
• W3034025107 startingPage "2249" @default.
• W3034025107 abstract "Lung cancer is the leading cause of cancer mortality worldwide. Drug resistance is the major barrier for the treatment of non-small cell lung cancer (NSCLC). The aim of this research is to develop an aptamer-decorated hybrid nanoparticle for the co-delivery of docetaxel prodrug (DTXp) and cisplatin (DDP) and to treat lung cancer.Aptamer-conjugated lipid-polymer ligands and redox-sensitive docetaxel prodrug were synthesized. DTXp and DDP were loaded into the lipid-polymer hybrid nanoparticles (LPHNs). The targeted efficiency of aptamer-decorated, DTXp and DDP co-encapsulated LPHNs (APT-DTXp/DDP-LPHNs) was determined by performing a cell uptake assay by flow cytometry-based analysis. In vivo biodistribution and anticancer efficiency of APT-DTXp/DDP-LPHNs were evaluated on NSCLC-bearing mice xenograft.APT-DTXp/DDP-LPHNs had a particle size of 213.5 ± 5.3 nm, with a zeta potential of 15.9 ± 1.9 mV. APT-DTXp/DDP-LPHNs exhibited a significantly enhanced cytotoxicity (drug concentration causing 50% inhibition was 0.71 ± 0.09 μg/mL), synergy antitumor effect (combination index was 0.62), and profound tumor inhibition ability (tumor inhibition ratio of 81.4%) compared with the non-aptamer-decorated LPHNs and single drug-loaded LPHNs.Since the synergistic effect of the drugs was found in this system, it would have great potential to inhibit lung tumor cells and in vivo tumor growth." @default.
• W3034025107 created "2020-06-12" @default.
• W3034025107 creator A5010541804 @default.
• W3034025107 creator A5018805094 @default.
• W3034025107 creator A5024440353 @default.
• W3034025107 creator A5026498644 @default.
• W3034025107 creator A5030147439 @default.
• W3034025107 creator A5045807480 @default.
• W3034025107 creator A5064121992 @default.
• W3034025107 creator A5073216396 @default.
• W3034025107 creator A5083079293 @default.
• W3034025107 date "2020-06-01" @default.
• W3034025107 modified "2023-10-10" @default.
• W3034025107 title "<p>Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles</p>" @default.
• W3034025107 cites W1684168371 @default.
• W3034025107 cites W1778816764 @default.
• W3034025107 cites W1848342177 @default.
• W3034025107 cites W1977545170 @default.
• W3034025107 cites W2027748446 @default.
• W3034025107 cites W2039850879 @default.
• W3034025107 cites W2057704227 @default.
• W3034025107 cites W2076396196 @default.
• W3034025107 cites W2077945404 @default.
• W3034025107 cites W2116266944 @default.
• W3034025107 cites W2203950387 @default.
• W3034025107 cites W2231802161 @default.
• W3034025107 cites W2346297396 @default.
• W3034025107 cites W2346894235 @default.
• W3034025107 cites W2484781770 @default.
• W3034025107 cites W2508112086 @default.
• W3034025107 cites W2508626444 @default.
• W3034025107 cites W2549873556 @default.
• W3034025107 cites W2615332588 @default.
• W3034025107 cites W2652162509 @default.
• W3034025107 cites W2746281865 @default.
• W3034025107 cites W2758752166 @default.
• W3034025107 cites W2776876541 @default.
• W3034025107 cites W2791084028 @default.
• W3034025107 cites W2791437922 @default.
• W3034025107 cites W2794604592 @default.
• W3034025107 cites W2795025719 @default.
• W3034025107 cites W2802318973 @default.
• W3034025107 cites W2810069728 @default.
• W3034025107 cites W2890271077 @default.
• W3034025107 cites W2890588194 @default.
• W3034025107 cites W2891140797 @default.
• W3034025107 cites W2892122806 @default.
• W3034025107 cites W2895403739 @default.
• W3034025107 cites W2896552274 @default.
• W3034025107 cites W2899684830 @default.
• W3034025107 cites W2900897374 @default.
• W3034025107 cites W2922303724 @default.
• W3034025107 cites W2946519580 @default.
• W3034025107 cites W2947640652 @default.
• W3034025107 cites W2955010346 @default.
• W3034025107 cites W2958628602 @default.
• W3034025107 cites W2963317177 @default.
• W3034025107 cites W2972078116 @default.
• W3034025107 cites W2973281672 @default.
• W3034025107 cites W2973577019 @default.
• W3034025107 cites W2978666811 @default.
• W3034025107 cites W2980042417 @default.
• W3034025107 cites W2986058762 @default.
• W3034025107 doi "https://doi.org/10.2147/dddt.s246574" @default.
• W3034025107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7293388" @default.
• W3034025107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32606595" @default.
• W3034025107 hasPublicationYear "2020" @default.
• W3034025107 type Work @default.
• W3034025107 sameAs 3034025107 @default.
• W3034025107 citedByCount "29" @default.
• W3034025107 countsByYear W30340251072021 @default.
• W3034025107 countsByYear W30340251072022 @default.
• W3034025107 countsByYear W30340251072023 @default.
• W3034025107 crossrefType "journal-article" @default.
• W3034025107 hasAuthorship W3034025107A5010541804 @default.
• W3034025107 hasAuthorship W3034025107A5018805094 @default.
• W3034025107 hasAuthorship W3034025107A5024440353 @default.
• W3034025107 hasAuthorship W3034025107A5026498644 @default.
• W3034025107 hasAuthorship W3034025107A5030147439 @default.
• W3034025107 hasAuthorship W3034025107A5045807480 @default.
• W3034025107 hasAuthorship W3034025107A5064121992 @default.
• W3034025107 hasAuthorship W3034025107A5073216396 @default.
• W3034025107 hasAuthorship W3034025107A5083079293 @default.
• W3034025107 hasBestOaLocation W30340251071 @default.
• W3034025107 hasConcept C108215921 @default.
• W3034025107 hasConcept C109316439 @default.
• W3034025107 hasConcept C121608353 @default.
• W3034025107 hasConcept C126322002 @default.
• W3034025107 hasConcept C128972844 @default.
• W3034025107 hasConcept C143998085 @default.
• W3034025107 hasConcept C150903083 @default.
• W3034025107 hasConcept C153911025 @default.
• W3034025107 hasConcept C185592680 @default.
• W3034025107 hasConcept C202751555 @default.
• W3034025107 hasConcept C207001950 @default.
• W3034025107 hasConcept C2776256026 @default.
• W3034025107 hasConcept C2776694085 @default.
• W3034025107 hasConcept C2777807558 @default.

• next