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• W3034028306 endingPage "274" @default.
• W3034028306 startingPage "274" @default.
• W3034028306 abstract "The development of therapeutic strategies to control the reactivation of the Herpes Simplex Virus (HSV) is an unaddressed priority. In this study, we evaluated whether Tat, a HIV-1 protein displaying adjuvant functions, could improve previously established HSV-specific memory responses and prevent viral reactivation. To this aim, mice were infected with non-lethal doses of HSV-1 and, 44 days later, injected or not with Tat. Mice were then monitored to check their health status and measure memory HSV-specific cellular and humoral responses. The appearance of symptoms associated with HSV-reactivation was observed at significantly higher frequencies in the control group than in the Tat-treated mice. In addition, the control animals experienced a time-dependent decrease in HSV-specific Immunoglobulin G (IgG), while the Tat-treated mice maintained antibody titers over time. IgG levels were directly correlated with the number of HSV-specific CD8+ T cells, suggesting an effect of Tat on both arms of the adaptive immunity. Consistent with the maintenance of HSV-specific immune memory, Tat-treated mice showed a better control of HSV-1 re-infection. Although further studies are necessary to assess whether similar effects are observed in other models, these results indicate that Tat exerts a therapeutic effect against latent HSV-1 infection and re-infection by favoring the maintenance of adaptive immunity." @default.
• W3034028306 created "2020-06-12" @default.
• W3034028306 creator A5001745874 @default.
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• W3034028306 creator A5083111559 @default.
• W3034028306 creator A5089989016 @default.
• W3034028306 date "2020-06-04" @default.
• W3034028306 modified "2023-10-16" @default.
• W3034028306 title "The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation" @default.
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• W3034028306 doi "https://doi.org/10.3390/vaccines8020274" @default.
• W3034028306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7349931" @default.
• W3034028306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32512757" @default.

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