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- W3034032495 abstract "At present, cervical cancer is the fourth leading cause of cancer among women worldwide with no effective treatment options. In this study we aimed to evaluate the efficacy of hypericin (HYP) encapsulated on Pluronic® P123 (HYP/P123) photodynamic therapy (PDT) in a comprehensive panel of human cervical cancer-derived cell lines, including HeLa (HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16 and 18-positive), and C33A (HPV-negative), compared to a nontumorigenic human epithelial cell line (HaCaT). Were investigated: (i) cell cytotoxicity and phototoxicity, cellular uptake and subcellular distribution; (ii) cell death pathway and cellular oxidative stress; (iii) migration and invasion. Our results showed that HYP/P123 micelles had effective and selective time- and dose-dependent phototoxic effects on cervical cancer cells but not in HaCaT. Moreover, HYP/P123 micelles accumulated in endoplasmic reticulum, mitochondria and lysosomes, resulting in photodynamic cell death mainly by necrosis. HYP/P123 induced cellular oxidative stress mainly via type II mechanism of PDT and inhibited cancer cell migration and invasion mainly via MMP-2 inhibition. Taken together, our results indicate a potentially useful role of HYP/P123 micelles as a platform for HYP delivery to more specifically and effectively treat cervical cancers through PDT, suggesting they are worthy for in vivo preclinical evaluations." @default.
- W3034032495 created "2020-06-12" @default.
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- W3034032495 date "2020-08-01" @default.
- W3034032495 modified "2023-10-03" @default.
- W3034032495 title "Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic®-based nanoparticles modulating hypericin delivery" @default.
- W3034032495 cites W1539357481 @default.
- W3034032495 cites W1596848781 @default.
- W3034032495 cites W159741139 @default.
- W3034032495 cites W1598408991 @default.
- W3034032495 cites W1687508156 @default.
- W3034032495 cites W1880313109 @default.
- W3034032495 cites W1916661321 @default.
- W3034032495 cites W1942176190 @default.
- W3034032495 cites W1943323865 @default.
- W3034032495 cites W1954387510 @default.
- W3034032495 cites W1963523161 @default.
- W3034032495 cites W1966304112 @default.
- W3034032495 cites W1968185731 @default.
- W3034032495 cites W1968379411 @default.
- W3034032495 cites W1975365466 @default.
- W3034032495 cites W1975367953 @default.
- W3034032495 cites W1978326395 @default.
- W3034032495 cites W1983408077 @default.
- W3034032495 cites W1987380570 @default.
- W3034032495 cites W1987531894 @default.
- W3034032495 cites W1994881394 @default.
- W3034032495 cites W1996595335 @default.
- W3034032495 cites W1998168743 @default.
- W3034032495 cites W1998204975 @default.
- W3034032495 cites W1999097629 @default.
- W3034032495 cites W2000216883 @default.
- W3034032495 cites W2003906765 @default.
- W3034032495 cites W2005435882 @default.
- W3034032495 cites W2005771407 @default.
- W3034032495 cites W2009828713 @default.
- W3034032495 cites W2014356708 @default.
- W3034032495 cites W2015472802 @default.
- W3034032495 cites W2016621959 @default.
- W3034032495 cites W2017599076 @default.
- W3034032495 cites W2018272990 @default.
- W3034032495 cites W2025285304 @default.
- W3034032495 cites W2026010448 @default.
- W3034032495 cites W2028373167 @default.
- W3034032495 cites W2029027308 @default.
- W3034032495 cites W2029114201 @default.
- W3034032495 cites W2031211419 @default.
- W3034032495 cites W2033345397 @default.
- W3034032495 cites W2036459378 @default.
- W3034032495 cites W2038095566 @default.
- W3034032495 cites W2038285275 @default.
- W3034032495 cites W2042518976 @default.
- W3034032495 cites W2042918517 @default.
- W3034032495 cites W2051482704 @default.
- W3034032495 cites W2054609339 @default.
- W3034032495 cites W2056913348 @default.
- W3034032495 cites W2057560126 @default.
- W3034032495 cites W2057906887 @default.
- W3034032495 cites W2061988562 @default.
- W3034032495 cites W2066445195 @default.
- W3034032495 cites W2071182478 @default.
- W3034032495 cites W2071393402 @default.
- W3034032495 cites W2076605566 @default.
- W3034032495 cites W2079794908 @default.
- W3034032495 cites W2082521803 @default.
- W3034032495 cites W2087861222 @default.
- W3034032495 cites W2090177988 @default.
- W3034032495 cites W2090750470 @default.
- W3034032495 cites W2091210609 @default.
- W3034032495 cites W2094874348 @default.
- W3034032495 cites W2096733107 @default.
- W3034032495 cites W2100592123 @default.
- W3034032495 cites W2105271234 @default.
- W3034032495 cites W2110413467 @default.
- W3034032495 cites W2116791229 @default.
- W3034032495 cites W2119569011 @default.
- W3034032495 cites W2122126311 @default.
- W3034032495 cites W2129575789 @default.
- W3034032495 cites W2129602105 @default.
- W3034032495 cites W2132834292 @default.
- W3034032495 cites W2134530080 @default.
- W3034032495 cites W2164106232 @default.
- W3034032495 cites W2166632132 @default.
- W3034032495 cites W2168238309 @default.
- W3034032495 cites W2170801813 @default.
- W3034032495 cites W2184277213 @default.