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• W3034046314 abstract "Summary Objective To investigate the association of polymorphisms of Pro12Ala of peroxisome proliferator-activated receptor gamma (PPARγ) gene with clinical and biochemical parameters in Uygur Chinese population with non-alcoholic fatty liver (NAFLD) Methods In this case–control study, we recruited 467 NAFLD cases and 524 controls. Examination of abdominal ultrasound, clinical and biochemical profiles, as well as polymerase chain reaction–restriction fragment length polymorphisms of Pro12Ala of PPARγ gene were performed. The association of PPARγ gene Pro12Ala variants with clinical and biochemical parameters was analyzed. Results There was no statistically significant difference between NAFLD and control groups in the frequencies of genotypic and allele distribution (P > 0.05), while significantly difference of genotypic (P = 0.032) and allele (P = 0.015) distribution was found between NAFLD and control groups in the obese. Using logistics multivariate regression analysis by adjusting age, sex, body mass index, diabetes, hyperuricemia and dyslipidemia, both Pro12Ala and Ala12Ala polymorphisms were not associated with the presence of NAFLD. However, above two polymorphisms were found to be related to NAFLD in obesity group (odds ratio = 0.442, P = 0.031 and odds ratio = 0.039, P = 0.010, respectively) Conclusion In Uygur Chinese population, PPARr gene Ala variants reduce the risk of NAFLD in obese individuals." @default.
• W3034046314 created "2020-06-12" @default.
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• W3034046314 date "2020-11-01" @default.
• W3034046314 modified "2023-10-16" @default.
• W3034046314 title "PPARγ gene Pro12Ala variants reduce the risk of obese individuals to non-alcoholic fatty liver: A study in Uygur Chinese population residing in Northwestern China" @default.
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• W3034046314 doi "https://doi.org/10.1016/j.clinre.2020.02.005" @default.
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