FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034058475> ?p ?o ?g. }

• W3034058475 endingPage "AB482" @default.
• W3034058475 startingPage "AB481" @default.
• W3034058475 abstract "In Asia, endoscopic submucosal dissection (ESD) is a technically mature, widely adopted resection method for early colorectal mucosal neoplasms (EMN). Adoption in the US lags far behind Asia and experience is limited, with literature primarily reporting on technical success and safety. We herein present our colorectal ESD experience since 2010, including long-term follow up results with >80% follow-up completion rate. We analyzed a prospective database of consecutive colorectal ESDs performed by a single operator at a high-volume referral center in the US. From 3/2010 to 11/2018, 377 patients had attempted ESD for 462 EMNs (42 carcinoma, 420 adenoma). Median patient age was 66 years. Prior biopsy, juxta-lesional Indian ink tattoo and attempted EMR+/-ablation was present in 432 (94%), 193 (42%) and 168 (36%) of lesions, respectively. 58 (13%) lesions were in the rectum and 351 (76%) were in the right colon. Lesions at ‘challenging” locations constituted 26% of the sample, including 36 (8%) sigmoid, 50 (11%) flexures, 25 (5%) ileocecal valve and 8 (2%) appendiceal orifice. Median lesion size was 3.2cm. Median ESD time was 56min. Median dissection speed was 11cm2/hr. En bloc and R0 resection were achieved in 427 (92.4%) and 389 (84.2%). Patients were admitted for a median of one day and 2.4% sustained clinically-significant adverse events, including 1 (0.3%) delayed perforation (inter-sphincteric abscess requiring incision and drainage), 6 (1.6%) delayed bleeding and 2 (0.5%) others. In the second half of our experience the case mix included larger (3.9 vs. 3.0 cm), and more manipulated lesions (prior EMR 43% vs 29%) but ESD was faster (ESD speed 13.0 vs. 7.5cm2/hr) and the en bloc and R0 resection rates were higher (en bloc 96.5% vs. 88.3%; R0 91.3% vs. 77.1%) consistent with learning effect (table 2). Follow-up at a median of 1 year was completed in 258/309 eligible patients (83.5%) with recurrence in only 2/258 (0.8%), all after resections early in our experience (2013-2014): both recurrences were noted at 1 and 2 years post R1 resection due to aborted ESD of large cecal lesions converted to piecemeal EMR. Data from our US referral center confirm similar colorectal ESD safety and efficacy as that reported by expert Asian centers. Despite a complex case mix including a high proportion of lesions with extensive manipulation and at difficult locations, R0 resection was achieved in 84% overall and 91% after the initial learning curve. Recurrence rate after ESD was 0.8% with recurrence after R0 ESD virtually non-existent which obviates the need for early surveillance. This major advantage of ESD should be taken into account in cost analyses of EMR vs ESD for colorectal lesions.Table 2Patient characteristics and procedure metrics in early phase vs late phase patients- series evolution and learning effectsView Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
• W3034058475 created "2020-06-12" @default.
• W3034058475 creator A5012795490 @default.
• W3034058475 creator A5036134475 @default.
• W3034058475 creator A5039466239 @default.
• W3034058475 creator A5041084104 @default.
• W3034058475 creator A5042923046 @default.
• W3034058475 creator A5049115168 @default.
• W3034058475 creator A5073172389 @default.
• W3034058475 creator A5086586679 @default.
• W3034058475 date "2020-06-01" @default.
• W3034058475 modified "2023-09-25" @default.
• W3034058475 title "Mo1750 ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL CANCER AND ADENOMA: A LARGE SINGLE-OPERATOR COHORT FROM THE USA WITH LONG-TERM FOLLOW UP" @default.
• W3034058475 doi "https://doi.org/10.1016/j.gie.2020.03.2944" @default.
• W3034058475 hasPublicationYear "2020" @default.
• W3034058475 type Work @default.
• W3034058475 sameAs 3034058475 @default.
• W3034058475 citedByCount "0" @default.
• W3034058475 crossrefType "journal-article" @default.
• W3034058475 hasAuthorship W3034058475A5012795490 @default.
• W3034058475 hasAuthorship W3034058475A5036134475 @default.
• W3034058475 hasAuthorship W3034058475A5039466239 @default.
• W3034058475 hasAuthorship W3034058475A5041084104 @default.
• W3034058475 hasAuthorship W3034058475A5042923046 @default.
• W3034058475 hasAuthorship W3034058475A5049115168 @default.
• W3034058475 hasAuthorship W3034058475A5073172389 @default.
• W3034058475 hasAuthorship W3034058475A5086586679 @default.
• W3034058475 hasBestOaLocation W30340584751 @default.
• W3034058475 hasConcept C121608353 @default.
• W3034058475 hasConcept C126322002 @default.
• W3034058475 hasConcept C126838900 @default.
• W3034058475 hasConcept C141071460 @default.
• W3034058475 hasConcept C188816634 @default.
• W3034058475 hasConcept C191897082 @default.
• W3034058475 hasConcept C192562407 @default.
• W3034058475 hasConcept C2775862295 @default.
• W3034058475 hasConcept C2776870353 @default.
• W3034058475 hasConcept C2777137803 @default.
• W3034058475 hasConcept C2777428134 @default.
• W3034058475 hasConcept C2778451229 @default.
• W3034058475 hasConcept C2778456384 @default.
• W3034058475 hasConcept C2778527123 @default.
• W3034058475 hasConcept C2778866283 @default.
• W3034058475 hasConcept C2780073493 @default.
• W3034058475 hasConcept C2781074409 @default.
• W3034058475 hasConcept C526805850 @default.
• W3034058475 hasConcept C71924100 @default.
• W3034058475 hasConceptScore W3034058475C121608353 @default.
• W3034058475 hasConceptScore W3034058475C126322002 @default.
• W3034058475 hasConceptScore W3034058475C126838900 @default.
• W3034058475 hasConceptScore W3034058475C141071460 @default.
• W3034058475 hasConceptScore W3034058475C188816634 @default.
• W3034058475 hasConceptScore W3034058475C191897082 @default.
• W3034058475 hasConceptScore W3034058475C192562407 @default.
• W3034058475 hasConceptScore W3034058475C2775862295 @default.
• W3034058475 hasConceptScore W3034058475C2776870353 @default.
• W3034058475 hasConceptScore W3034058475C2777137803 @default.
• W3034058475 hasConceptScore W3034058475C2777428134 @default.
• W3034058475 hasConceptScore W3034058475C2778451229 @default.
• W3034058475 hasConceptScore W3034058475C2778456384 @default.
• W3034058475 hasConceptScore W3034058475C2778527123 @default.
• W3034058475 hasConceptScore W3034058475C2778866283 @default.
• W3034058475 hasConceptScore W3034058475C2780073493 @default.
• W3034058475 hasConceptScore W3034058475C2781074409 @default.
• W3034058475 hasConceptScore W3034058475C526805850 @default.
• W3034058475 hasConceptScore W3034058475C71924100 @default.
• W3034058475 hasIssue "6" @default.
• W3034058475 hasLocation W30340584751 @default.
• W3034058475 hasOpenAccess W3034058475 @default.
• W3034058475 hasPrimaryLocation W30340584751 @default.
• W3034058475 hasRelatedWork W1842558946 @default.
• W3034058475 hasRelatedWork W1883188551 @default.
• W3034058475 hasRelatedWork W2008416109 @default.
• W3034058475 hasRelatedWork W2011908171 @default.
• W3034058475 hasRelatedWork W2044285477 @default.
• W3034058475 hasRelatedWork W2058589189 @default.
• W3034058475 hasRelatedWork W2075111454 @default.
• W3034058475 hasRelatedWork W2552807093 @default.
• W3034058475 hasRelatedWork W2810873673 @default.
• W3034058475 hasRelatedWork W3028763767 @default.
• W3034058475 hasVolume "91" @default.
• W3034058475 isParatext "false" @default.
• W3034058475 isRetracted "false" @default.
• W3034058475 magId "3034058475" @default.
• W3034058475 workType "article" @default.