Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034078572> ?p ?o ?g. }
- W3034078572 endingPage "105789" @default.
- W3034078572 startingPage "105789" @default.
- W3034078572 abstract "Hepatocellular carcinoma (HCC) is a fatal disease characterized by poor liver function with increasing morbidity and poor prognosis. Extracellular vesicles, released by different cells, have been associated with HCC development. Nevertheless, the mechanisms beyond extracellular vesicles in HCC remain uncharacterized. Therefore, the current study aimed to clarify the mechanism of pro-angiogenic microRNA-584-5p in hepatocellular carcinoma. Our results showed that miR-584-5p was highly-expressed in both cancer cells (Hep3B) and their extracellular vesicles. Hep3B and extracellular vesicles were then respectively co-cultured with human vascular endothelial cell line (Ea.hy926), and they both accelerated Ea.hy926 proliferation and migration. Ea.hy926 cells could internalize extracellular vesicles carrying microRNA-584-5p. Of note, microRNA-584-5p could bind to phosphoenolpyruvate carboxykinase 1 to promote nuclear factor E2-related factor 2. Moreover, silencing microRNA-584-5p was found to decline microvessel density, vascular endothelial growth factor A, and tumor growth in vivo and in vitro. Taken altogether, our findings demonstrated that extracellular vesicles-derived microRNA-584-5p promotes angiogenesis by inhibiting PCK1 -mediating NRF2 activation, which highlights the theoretical basis for potential treatments for HCC." @default.
- W3034078572 created "2020-06-12" @default.
- W3034078572 creator A5005349597 @default.
- W3034078572 creator A5087828546 @default.
- W3034078572 creator A5091851978 @default.
- W3034078572 date "2020-08-01" @default.
- W3034078572 modified "2023-09-26" @default.
- W3034078572 title "Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway" @default.
- W3034078572 cites W1768951556 @default.
- W3034078572 cites W2055224521 @default.
- W3034078572 cites W2148995089 @default.
- W3034078572 cites W2214223681 @default.
- W3034078572 cites W2231905968 @default.
- W3034078572 cites W2313670286 @default.
- W3034078572 cites W2319962899 @default.
- W3034078572 cites W2463234131 @default.
- W3034078572 cites W2469619651 @default.
- W3034078572 cites W2515188071 @default.
- W3034078572 cites W2556350558 @default.
- W3034078572 cites W2588025094 @default.
- W3034078572 cites W2589608248 @default.
- W3034078572 cites W2681768872 @default.
- W3034078572 cites W2706098188 @default.
- W3034078572 cites W2738744058 @default.
- W3034078572 cites W2750040561 @default.
- W3034078572 cites W2752067270 @default.
- W3034078572 cites W2766608748 @default.
- W3034078572 cites W2783932169 @default.
- W3034078572 cites W2784415013 @default.
- W3034078572 cites W2784637237 @default.
- W3034078572 cites W2795780116 @default.
- W3034078572 cites W2797662866 @default.
- W3034078572 cites W2800218175 @default.
- W3034078572 cites W2808293799 @default.
- W3034078572 cites W2898511841 @default.
- W3034078572 cites W2901254223 @default.
- W3034078572 cites W2903872251 @default.
- W3034078572 cites W2903961260 @default.
- W3034078572 cites W2906666501 @default.
- W3034078572 cites W2912676549 @default.
- W3034078572 cites W2918023653 @default.
- W3034078572 cites W2921283762 @default.
- W3034078572 cites W2942703899 @default.
- W3034078572 cites W2946307682 @default.
- W3034078572 cites W2948893547 @default.
- W3034078572 cites W2954280220 @default.
- W3034078572 doi "https://doi.org/10.1016/j.biocel.2020.105789" @default.
- W3034078572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32522621" @default.
- W3034078572 hasPublicationYear "2020" @default.
- W3034078572 type Work @default.
- W3034078572 sameAs 3034078572 @default.
- W3034078572 citedByCount "12" @default.
- W3034078572 countsByYear W30340785722021 @default.
- W3034078572 countsByYear W30340785722022 @default.
- W3034078572 countsByYear W30340785722023 @default.
- W3034078572 crossrefType "journal-article" @default.
- W3034078572 hasAuthorship W3034078572A5005349597 @default.
- W3034078572 hasAuthorship W3034078572A5087828546 @default.
- W3034078572 hasAuthorship W3034078572A5091851978 @default.
- W3034078572 hasConcept C104317684 @default.
- W3034078572 hasConcept C119056186 @default.
- W3034078572 hasConcept C145059251 @default.
- W3034078572 hasConcept C146285616 @default.
- W3034078572 hasConcept C167734588 @default.
- W3034078572 hasConcept C20518536 @default.
- W3034078572 hasConcept C2777025900 @default.
- W3034078572 hasConcept C2780394083 @default.
- W3034078572 hasConcept C28406088 @default.
- W3034078572 hasConcept C2908689518 @default.
- W3034078572 hasConcept C502942594 @default.
- W3034078572 hasConcept C53673613 @default.
- W3034078572 hasConcept C55493867 @default.
- W3034078572 hasConcept C86803240 @default.
- W3034078572 hasConcept C95444343 @default.
- W3034078572 hasConceptScore W3034078572C104317684 @default.
- W3034078572 hasConceptScore W3034078572C119056186 @default.
- W3034078572 hasConceptScore W3034078572C145059251 @default.
- W3034078572 hasConceptScore W3034078572C146285616 @default.
- W3034078572 hasConceptScore W3034078572C167734588 @default.
- W3034078572 hasConceptScore W3034078572C20518536 @default.
- W3034078572 hasConceptScore W3034078572C2777025900 @default.
- W3034078572 hasConceptScore W3034078572C2780394083 @default.
- W3034078572 hasConceptScore W3034078572C28406088 @default.
- W3034078572 hasConceptScore W3034078572C2908689518 @default.
- W3034078572 hasConceptScore W3034078572C502942594 @default.
- W3034078572 hasConceptScore W3034078572C53673613 @default.
- W3034078572 hasConceptScore W3034078572C55493867 @default.
- W3034078572 hasConceptScore W3034078572C86803240 @default.
- W3034078572 hasConceptScore W3034078572C95444343 @default.
- W3034078572 hasLocation W30340785721 @default.
- W3034078572 hasLocation W30340785722 @default.
- W3034078572 hasOpenAccess W3034078572 @default.
- W3034078572 hasPrimaryLocation W30340785721 @default.
- W3034078572 hasRelatedWork W1990602103 @default.
- W3034078572 hasRelatedWork W2161617639 @default.
- W3034078572 hasRelatedWork W2260459001 @default.
- W3034078572 hasRelatedWork W2464399839 @default.
- W3034078572 hasRelatedWork W2786514708 @default.