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- W3034102435 endingPage "2530" @default.
- W3034102435 startingPage "2530" @default.
- W3034102435 abstract "Thermoresponsive hydrogels demonstrate tremendous potential as sustained drug delivery systems. However, progress has been limited as formulation of a stable biodegradable thermosensitive hydrogel remains a significant challenge. In this study, free radical polymerization was exploited to formulate a biodegradable thermosensitive hydrogel characterized by sustained drug release. Highly deacetylated chitosan and N-isopropylacrylamide with distinctive physical properties were employed to achieve a stable, hydrogel network at body temperature. The percentage of chitosan was altered within the copolymer formulations and the subsequent physical properties were characterized using 1H-NMR, FTIR, and TGA. Viscoelastic, swelling, and degradation properties were also interrogated. The thermoresponsive hydrogels were loaded with RALA/pEGFP-N1 nanoparticles and release was examined. There was sustained release of nanoparticles over three weeks and, more importantly, the nucleic acid cargo remained functional and this was confirmed by successful transfection of the NCTC-929 fibroblast cell line. This tailored thermoresponsive hydrogel offers an option for sustained delivery of macromolecules over a prolonged considerable period." @default.
- W3034102435 created "2020-06-12" @default.
- W3034102435 creator A5014770050 @default.
- W3034102435 creator A5065260839 @default.
- W3034102435 creator A5081151755 @default.
- W3034102435 creator A5087663313 @default.
- W3034102435 creator A5087701517 @default.
- W3034102435 date "2020-06-02" @default.
- W3034102435 modified "2023-10-11" @default.
- W3034102435 title "Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System" @default.
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