Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034105946> ?p ?o ?g. }
- W3034105946 endingPage "113534" @default.
- W3034105946 startingPage "113534" @default.
- W3034105946 abstract "Results of zeta potential measurements and of spectroscopic (increased solubility, equilibrium dialysis, 1H NMR titration) and calorimetric measurements (isothermal ITC titration) indicate that fourth generation poly(propyleneimine) dendrimer (PPI G4) spontaneously binds (∆G < 0) 5-fluorouracil (FU) molecules in aqueous environments. The poly(propyleneimine) G4 dendrimer binds approximately n = 42 ± 3 drug molecules with an equilibrium constant of K = 220 ± 30. The process of saturation of dendrimer active centres with drug molecules is exothermic (∆H < 0) and accompanied by increased ordering of reagents (∆S < 0). Results of equilibrium dialysis indicate that poly(propyleneimine) G4 dendrimer has two sets of active centres comprising: n1 = 5 ± 1 sites with higher binding constant towards 5-fluorouracil and n2 = 39 ± 3 sites with lower binding constant towards this particular drug. The obtained results of a study on binding of 5-fluorouracil by the poly(propyleneimine) G4 dendrimer were compared with results for binding of this drug by poly (amidoamine) (PAMAM) G4 dendrimer macromolecules with the same number of surface, primary amine groups." @default.
- W3034105946 created "2020-06-12" @default.
- W3034105946 creator A5001998987 @default.
- W3034105946 creator A5056270027 @default.
- W3034105946 creator A5058045398 @default.
- W3034105946 creator A5067228724 @default.
- W3034105946 date "2020-09-01" @default.
- W3034105946 modified "2023-10-16" @default.
- W3034105946 title "Spectroscopic, electrochemical and calorimetric studies on the interactions of poly(propyleneimine) G4 dendrimer with 5-fluorouracil in aqueous solutions" @default.
- W3034105946 cites W1007646433 @default.
- W3034105946 cites W1553692161 @default.
- W3034105946 cites W1573111014 @default.
- W3034105946 cites W1581088900 @default.
- W3034105946 cites W1592387620 @default.
- W3034105946 cites W1861980204 @default.
- W3034105946 cites W1974322101 @default.
- W3034105946 cites W1981688934 @default.
- W3034105946 cites W1983649348 @default.
- W3034105946 cites W1989983528 @default.
- W3034105946 cites W1994171881 @default.
- W3034105946 cites W1994543965 @default.
- W3034105946 cites W2016002392 @default.
- W3034105946 cites W2023498315 @default.
- W3034105946 cites W2023779015 @default.
- W3034105946 cites W2025708633 @default.
- W3034105946 cites W2027171801 @default.
- W3034105946 cites W2032675837 @default.
- W3034105946 cites W2033371230 @default.
- W3034105946 cites W2038215682 @default.
- W3034105946 cites W2038756315 @default.
- W3034105946 cites W2042940583 @default.
- W3034105946 cites W2043764483 @default.
- W3034105946 cites W2043887858 @default.
- W3034105946 cites W2049864113 @default.
- W3034105946 cites W2063932206 @default.
- W3034105946 cites W2072707684 @default.
- W3034105946 cites W2085262120 @default.
- W3034105946 cites W2087212977 @default.
- W3034105946 cites W2087286558 @default.
- W3034105946 cites W2088467380 @default.
- W3034105946 cites W2091458141 @default.
- W3034105946 cites W2092416873 @default.
- W3034105946 cites W2110077313 @default.
- W3034105946 cites W2126326947 @default.
- W3034105946 cites W2134142320 @default.
- W3034105946 cites W2142513212 @default.
- W3034105946 cites W2146642389 @default.
- W3034105946 cites W2150328178 @default.
- W3034105946 cites W2203945740 @default.
- W3034105946 cites W2263038367 @default.
- W3034105946 cites W2289888427 @default.
- W3034105946 cites W2314302342 @default.
- W3034105946 cites W2315784420 @default.
- W3034105946 cites W2323033888 @default.
- W3034105946 cites W2324186795 @default.
- W3034105946 cites W2325079389 @default.
- W3034105946 cites W2353220926 @default.
- W3034105946 cites W2361149520 @default.
- W3034105946 cites W2473363847 @default.
- W3034105946 cites W2508839905 @default.
- W3034105946 cites W2508976970 @default.
- W3034105946 cites W2538937748 @default.
- W3034105946 cites W2541057171 @default.
- W3034105946 cites W2544456663 @default.
- W3034105946 cites W2614780414 @default.
- W3034105946 cites W2749722012 @default.
- W3034105946 cites W2780514589 @default.
- W3034105946 cites W2791391115 @default.
- W3034105946 cites W2792256559 @default.
- W3034105946 cites W2797753642 @default.
- W3034105946 cites W2807398436 @default.
- W3034105946 cites W2807779920 @default.
- W3034105946 cites W2809948541 @default.
- W3034105946 cites W2890435831 @default.
- W3034105946 cites W2899134141 @default.
- W3034105946 cites W2899184101 @default.
- W3034105946 cites W2907585797 @default.
- W3034105946 cites W2908049261 @default.
- W3034105946 cites W2910051461 @default.
- W3034105946 cites W2917620326 @default.
- W3034105946 cites W2920049210 @default.
- W3034105946 cites W2940184018 @default.
- W3034105946 cites W2940201097 @default.
- W3034105946 cites W2941185641 @default.
- W3034105946 cites W2991569831 @default.
- W3034105946 doi "https://doi.org/10.1016/j.molliq.2020.113534" @default.
- W3034105946 hasPublicationYear "2020" @default.
- W3034105946 type Work @default.
- W3034105946 sameAs 3034105946 @default.
- W3034105946 citedByCount "2" @default.
- W3034105946 countsByYear W30341059462021 @default.
- W3034105946 countsByYear W30341059462022 @default.
- W3034105946 crossrefType "journal-article" @default.
- W3034105946 hasAuthorship W3034105946A5001998987 @default.
- W3034105946 hasAuthorship W3034105946A5056270027 @default.
- W3034105946 hasAuthorship W3034105946A5058045398 @default.
- W3034105946 hasAuthorship W3034105946A5067228724 @default.
- W3034105946 hasConcept C103319777 @default.