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• W3034117548 abstract "The inflammatory response has been implicated in various cardiac and systemic diseases. Epigallocatechin‑3‑gallate (EGCG), the major polyphenol extracted from green tea, has various biological and pharmacological properties, such as anti‑inflammation, anti‑oxidative and anti‑tumorigenesis. To some extent, the mechanism of EGCG in the inflammatory response that characterizes myocardial dysfunction is not fully understood. The present study aimed to investigate the inhibiting effect of EGCG on lipopolysaccharide (LPS)‑induced inflammation in vitro. Treatment with LPS affected rat H9c2 cardiomyocytes and induced an inflammatory response. However, the LPS‑induced effects were attenuated after treatment with EGCG. The present results demonstrated that EGCG treatment repressed several inflammatory mediators, such as vascular endothelial growth factor, chemokine ligand 5, chemokine ligand 2, intercellular adhesion molecule‑1, matrix metalloproteinase‑2, tumor necrosis factor‑α and nitric oxide (induced by LPS), and the repressing effect of EGCG on inflammatory response was dose‑dependent in the range of 6.25‑100 µM. EGCG inhibited these marked inflammatory key signaling molecules by reducing the expression of phospho‑nuclear factor‑κB p65, ‑Akt, ‑ERK and ‑MAPK p38 while the total protein level of these signal proteins were not affected. In conclusion, the present findings suggested that EGCG possesses cardiomyocyte‑protective action in reducing the LPS‑induced inflammatory response due to the inhibition of the phosphorylation of Akt and ERK signaling molecules." @default.
• W3034117548 created "2020-06-12" @default.
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• W3034117548 date "2020-06-03" @default.
• W3034117548 modified "2023-09-29" @default.
• W3034117548 title "Epigallocatechin‑3‑gallate ameliorates LPS‑induced inflammation by inhibiting the phosphorylation of Akt and ERK signaling molecules in rat H9c2 cells" @default.
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• W3034117548 doi "https://doi.org/10.3892/etm.2020.8827" @default.
• W3034117548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7388411" @default.
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