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- W3034130666 abstract "Single-stranded DNA or RNA oligonucleotides, often called aptamers, can bind to a molecular target with both high affinity and selectivity due to their distinct three-dimensional structures. A technique called systematic evolution of ligands by exponential enrichment (SELEX) is used to screen aptamers from a random DNA or RNA pool, or library. The traditionally-designed oligonucleotides in libraries contain a randomized central region along with a fixed primer region at each end for amplifying target-bound central sequences. The single-stranded forward and reverse primer sequences may interfere with target-binding to the central region, resulting in a partial or complete loss of high-affinity aptamers during the SELEX process. To address this issue, researchers have modified the traditional oligonucleotide libraries and developed new types of oligonucleotide libraries; however, these approaches come with various limitations. The author proposes a new design that uses a conformation-changeable sequence as primers, which may open a new avenue for developing an optimized aptamer sequence with both high affinity for, and selective binding to, a particular target via SELEX." @default.
- W3034130666 created "2020-06-12" @default.
- W3034130666 creator A5005542617 @default.
- W3034130666 date "2020-06-05" @default.
- W3034130666 modified "2023-10-12" @default.
- W3034130666 title "A New Design for the Fixed Primer Regions in an Oligonucleotide Library for SELEX Aptamer Screening" @default.
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- W3034130666 doi "https://doi.org/10.3389/fchem.2020.00475" @default.
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