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- W3034149594 endingPage "527" @default.
- W3034149594 startingPage "527" @default.
- W3034149594 abstract "The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN." @default.
- W3034149594 created "2020-06-12" @default.
- W3034149594 creator A5053234879 @default.
- W3034149594 creator A5082298443 @default.
- W3034149594 date "2020-06-08" @default.
- W3034149594 modified "2023-10-16" @default.
- W3034149594 title "Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy" @default.
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