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- W3034149729 abstract "Abstract Group A rotavirus (RVA) rarely causes severe complications such as encephalitis/encephalopathy. However, the pathophysiology of this specific complication remains unclear. Next‐generation sequence analysis was used to compare the entire genome sequences of RVAs detected in patients with encephalitis/encephalopathy and gastroenteritis. This study enrolled eight patients with RVA encephalitis/encephalopathy and 10 with RVA gastroenteritis who were treated between February 2013 and July 2014. Viral RNAs were extracted from patients' stool, and whole‐genome sequencing analysis was carried out to identify the specific gene mutations in RVA obtained from patients with severe neurological complications. Among the eight encephalitis/encephalopathy cases, six strains were DS‐1‐like G1P[8] and the remaining two were Wa‐like G1P[8] (G1‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1). Meanwhile, eight of the 10 viruses detected in rotavirus gastroenteritis patients were DS‐1‐like G1P[8], and the remaining two were Wa‐like G1P[8]. These strains were further characterized by conducting phylogenetic analysis. No specific clustering was demonstrated in RVAs detected from encephalitis/encephalopathy patients. Although the DS‐1‐like G1P[8] strain was predominant in both groups, no specific molecular characteristics were detected in RVAs from patients with severe central nervous system complications." @default.
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- W3034149729 date "2020-08-01" @default.
- W3034149729 modified "2023-09-27" @default.
- W3034149729 title "Molecular characterization of rotaviruses obtained from patients with rotavirus‐associated encephalitis/encephalopathy" @default.
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- W3034149729 doi "https://doi.org/10.1111/1348-0421.12827" @default.
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