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- W3034156734 endingPage "14330" @default.
- W3034156734 startingPage "14322" @default.
- W3034156734 abstract "Phosphorothioate (PT) DNA modifications—in which a nonbonding phosphate oxygen is replaced with sulfur—represent a widespread, horizontally transferred epigenetic system in prokaryotes and have a highly unusual property of occupying only a small fraction of available consensus sequences in a genome. Using Salmonella enterica as a model, we asked a question of fundamental importance: How do the PT-modifying DndA-E proteins select their G PS AAC/G PS TTC targets? Here, we applied innovative analytical, sequencing, and computational tools to discover a novel behavior for DNA-binding proteins: The Dnd proteins are “parked” at the G 6m ATC Dam methyltransferase consensus sequence instead of the expected GAAC/GTTC motif, with removal of the 6m A permitting extensive PT modification of GATC sites. This shift in modification sites further revealed a surprising constancy in the density of PT modifications across the genome. Computational analysis showed that GAAC, GTTC, and GATC share common features of DNA shape, which suggests that PT epigenetics are regulated in a density-dependent manner partly by DNA shape-driven target selection in the genome." @default.
- W3034156734 created "2020-06-12" @default.
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- W3034156734 date "2020-06-09" @default.
- W3034156734 modified "2023-10-16" @default.
- W3034156734 title "Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria" @default.
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- W3034156734 doi "https://doi.org/10.1073/pnas.2002933117" @default.
- W3034156734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7322087" @default.
- W3034156734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32518115" @default.
- W3034156734 hasPublicationYear "2020" @default.
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