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- W3034173713 endingPage "103014" @default.
- W3034173713 startingPage "103014" @default.
- W3034173713 abstract "Cancer immunotherapy using checkpoint blockade has brought about a paradigm shift in the treatment of advanced-stage cancers. Unfortunately, not all patients benefit from these therapies, paving the way for other immune checkpoints to be targeted. CD47, a 'marker-of-self' protein that is overexpressed broadly across tumor types, is emerging as a novel potent macrophage immune checkpoint for cancer immunotherapy. Recently, CD47 blockade by Hu5F9-G4 has shown promise combined with Rituximab in non-Hodgkin's lymphoma. Here we review the complex structure and various physiological functions of CD47 and their implications in cancer biology. Further, this review considers future directions and challenges in advancing this promising target platform to widespread therapeutic use." @default.
- W3034173713 created "2020-06-12" @default.
- W3034173713 creator A5007605414 @default.
- W3034173713 creator A5011130572 @default.
- W3034173713 creator A5036143258 @default.
- W3034173713 creator A5045761365 @default.
- W3034173713 date "2020-08-01" @default.
- W3034173713 modified "2023-10-17" @default.
- W3034173713 title "CD47: the next checkpoint target for cancer immunotherapy" @default.
- W3034173713 cites W1567033666 @default.
- W3034173713 cites W1853160207 @default.
- W3034173713 cites W1907947122 @default.
- W3034173713 cites W1957657505 @default.
- W3034173713 cites W1966217032 @default.
- W3034173713 cites W1969412365 @default.
- W3034173713 cites W1971063170 @default.
- W3034173713 cites W1974531833 @default.
- W3034173713 cites W2009148545 @default.
- W3034173713 cites W2018917333 @default.
- W3034173713 cites W2028407058 @default.
- W3034173713 cites W2028890259 @default.
- W3034173713 cites W2035478255 @default.
- W3034173713 cites W2039949492 @default.
- W3034173713 cites W2059313294 @default.
- W3034173713 cites W2067975406 @default.
- W3034173713 cites W2076781845 @default.
- W3034173713 cites W2087915132 @default.
- W3034173713 cites W2089547141 @default.
- W3034173713 cites W2089881927 @default.
- W3034173713 cites W2091133773 @default.
- W3034173713 cites W2093455126 @default.
- W3034173713 cites W2094502174 @default.
- W3034173713 cites W2094548766 @default.
- W3034173713 cites W2097126393 @default.
- W3034173713 cites W2097733789 @default.
- W3034173713 cites W2099467740 @default.
- W3034173713 cites W2101513390 @default.
- W3034173713 cites W2103170395 @default.
- W3034173713 cites W2103746815 @default.
- W3034173713 cites W2106545303 @default.
- W3034173713 cites W2114331758 @default.
- W3034173713 cites W2116607009 @default.
- W3034173713 cites W2119670049 @default.
- W3034173713 cites W2129645310 @default.
- W3034173713 cites W2130869560 @default.
- W3034173713 cites W2133346943 @default.
- W3034173713 cites W2133725847 @default.
- W3034173713 cites W2139418176 @default.
- W3034173713 cites W2141638428 @default.
- W3034173713 cites W2143890525 @default.
- W3034173713 cites W2145740810 @default.
- W3034173713 cites W2154672378 @default.
- W3034173713 cites W2167798168 @default.
- W3034173713 cites W2179179825 @default.
- W3034173713 cites W2257916459 @default.
- W3034173713 cites W2259285103 @default.
- W3034173713 cites W2259730793 @default.
- W3034173713 cites W2299181842 @default.
- W3034173713 cites W2339658610 @default.
- W3034173713 cites W2472917228 @default.
- W3034173713 cites W2550646651 @default.
- W3034173713 cites W2554618897 @default.
- W3034173713 cites W2559024717 @default.
- W3034173713 cites W2570618306 @default.
- W3034173713 cites W2588025094 @default.
- W3034173713 cites W2592323349 @default.
- W3034173713 cites W2592953803 @default.
- W3034173713 cites W2594014934 @default.
- W3034173713 cites W2597064996 @default.
- W3034173713 cites W2614438066 @default.
- W3034173713 cites W2619087203 @default.
- W3034173713 cites W2635951006 @default.
- W3034173713 cites W2768892314 @default.
- W3034173713 cites W2768951490 @default.
- W3034173713 cites W2783137027 @default.
- W3034173713 cites W2786816161 @default.
- W3034173713 cites W2791342692 @default.
- W3034173713 cites W2792850123 @default.
- W3034173713 cites W2797008586 @default.
- W3034173713 cites W2799443762 @default.
- W3034173713 cites W2804364560 @default.
- W3034173713 cites W2878837766 @default.
- W3034173713 cites W2888380195 @default.
- W3034173713 cites W2889895672 @default.
- W3034173713 cites W2890786500 @default.
- W3034173713 cites W2899044337 @default.
- W3034173713 cites W2901758876 @default.
- W3034173713 cites W2903169490 @default.
- W3034173713 cites W2912724961 @default.
- W3034173713 cites W2920905579 @default.
- W3034173713 cites W2921760704 @default.
- W3034173713 cites W4236564205 @default.
- W3034173713 cites W2021586066 @default.
- W3034173713 doi "https://doi.org/10.1016/j.critrevonc.2020.103014" @default.
- W3034173713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32535479" @default.
- W3034173713 hasPublicationYear "2020" @default.
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