FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034176048> ?p ?o ?g. }

• W3034176048 endingPage "117957272091494" @default.
• W3034176048 startingPage "117957272091494" @default.
• W3034176048 abstract "The use of the topical nonsteroidal anti-inflammatory drugs (NSAID) ibuprofen for the treatment of knee osteoarthritis. Supporting clinician decision-making in the first-line treatment of osteoarthritis.To open discussion at a clinical level on the guidelines for the pharmacological management of osteoarthritis of the knee, this narrative review looks into the use of topical NSAID being a clinically effective, safe, and cost-efficient treatment compared to an oral alternative.With the over prescription of NSAIDs in the age of above 65 years, there has been a call for increased restrictions of the sale of oral preparations of NSAIDs. It is our view that there is still a lack of awareness in the benefit of topical NSAIDs to the patient (no evidence of adverse reactions recorded by the Joint Formulary Committee [JFC] to date) as well as provider (topical application is cheaper as a National Health Service [NHS] prescription).Key online resources included PubMed, Athens, Cochrane Library, Google Scholar, MEDLINE, and relevant clinical and commissioning guidelines with the final date of data collection in March 2017. We also contacted the manufacturer and license holder directly for further clarification. Randomized, double-blind control studies, commissioned reports, International Guidelines, MEHA Guidelines, and license holder data were included. Where possible studies included had to have fair randomization and adhere to key treatment pathways as highlighted by National Institute for Health and Clinical Excellence (NICE) and other guidelines.Current guidelines advise that patients who seek initial treatment of osteoarthritis of the knee should consider a combination of treatment modalities, including pharmacological therapies, particularly the use of NSAIDs. At a clinical level, a reoccurring issue identified with this advice is the inappropriate use of oral NSAIDs, and the concern that the risks associated with ease of access (over the counter), and overuse, may result in systemic adverse events in this cohort of patients. Multiple studies have examined the negative effect of oral NSAIDs and the associated risks of use. We were unable to source studies that showed any adverse systemic events from the use of topical NSAIDs; however, there are good quality trials comparing oral to topical NSAIDs, showing similar levels of efficacy at 6 and 12 weeks.Topical NSAIDs provide good levels of pain relief in subjects with mild to moderate knee osteoarthritis. There is also evidence for the use of the topical application being a clinically effective, safe, and cost-efficient treatment." @default.
• W3034176048 created "2020-06-19" @default.
• W3034176048 creator A5043177373 @default.
• W3034176048 date "2020-01-01" @default.
• W3034176048 modified "2023-09-26" @default.
• W3034176048 title "A Narrative Review: The Use of the Topical NSAID Ibuprofen for the Treatment of Knee Osteoarthritis. Supporting Clinician Decision-Making in the First-Line Treatment of Osteoarthritis" @default.
• W3034176048 cites W1494229485 @default.
• W3034176048 cites W1591138153 @default.
• W3034176048 cites W1595124760 @default.
• W3034176048 cites W1885984403 @default.
• W3034176048 cites W1890512155 @default.
• W3034176048 cites W1983018492 @default.
• W3034176048 cites W2008677544 @default.
• W3034176048 cites W2036491373 @default.
• W3034176048 cites W2054772763 @default.
• W3034176048 cites W2084289720 @default.
• W3034176048 cites W2092890771 @default.
• W3034176048 cites W2115805053 @default.
• W3034176048 cites W2117823128 @default.
• W3034176048 cites W2164287243 @default.
• W3034176048 cites W2167792025 @default.
• W3034176048 cites W2170132723 @default.
• W3034176048 cites W2268120541 @default.
• W3034176048 cites W4376595560 @default.
• W3034176048 cites W64291478 @default.
• W3034176048 doi "https://doi.org/10.1177/1179572720914945" @default.
• W3034176048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8282155" @default.
• W3034176048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34497464" @default.
• W3034176048 hasPublicationYear "2020" @default.
• W3034176048 type Work @default.
• W3034176048 sameAs 3034176048 @default.
• W3034176048 citedByCount "2" @default.
• W3034176048 countsByYear W30341760482022 @default.
• W3034176048 crossrefType "journal-article" @default.
• W3034176048 hasAuthorship W3034176048A5043177373 @default.
• W3034176048 hasBestOaLocation W30341760481 @default.
• W3034176048 hasConcept C100406419 @default.
• W3034176048 hasConcept C126322002 @default.
• W3034176048 hasConcept C141071460 @default.
• W3034176048 hasConcept C142724271 @default.
• W3034176048 hasConcept C159110408 @default.
• W3034176048 hasConcept C168563851 @default.
• W3034176048 hasConcept C17744445 @default.
• W3034176048 hasConcept C177713679 @default.
• W3034176048 hasConcept C1862650 @default.
• W3034176048 hasConcept C199360897 @default.
• W3034176048 hasConcept C199539241 @default.
• W3034176048 hasConcept C204787440 @default.
• W3034176048 hasConcept C2426938 @default.
• W3034176048 hasConcept C2776164576 @default.
• W3034176048 hasConcept C2776478404 @default.
• W3034176048 hasConcept C2779256446 @default.
• W3034176048 hasConcept C2779473830 @default.
• W3034176048 hasConcept C2779944601 @default.
• W3034176048 hasConcept C3020000205 @default.
• W3034176048 hasConcept C41008148 @default.
• W3034176048 hasConcept C512399662 @default.
• W3034176048 hasConcept C535046627 @default.
• W3034176048 hasConcept C71924100 @default.
• W3034176048 hasConcept C98274493 @default.
• W3034176048 hasConceptScore W3034176048C100406419 @default.
• W3034176048 hasConceptScore W3034176048C126322002 @default.
• W3034176048 hasConceptScore W3034176048C141071460 @default.
• W3034176048 hasConceptScore W3034176048C142724271 @default.
• W3034176048 hasConceptScore W3034176048C159110408 @default.
• W3034176048 hasConceptScore W3034176048C168563851 @default.
• W3034176048 hasConceptScore W3034176048C17744445 @default.
• W3034176048 hasConceptScore W3034176048C177713679 @default.
• W3034176048 hasConceptScore W3034176048C1862650 @default.
• W3034176048 hasConceptScore W3034176048C199360897 @default.
• W3034176048 hasConceptScore W3034176048C199539241 @default.
• W3034176048 hasConceptScore W3034176048C204787440 @default.
• W3034176048 hasConceptScore W3034176048C2426938 @default.
• W3034176048 hasConceptScore W3034176048C2776164576 @default.
• W3034176048 hasConceptScore W3034176048C2776478404 @default.
• W3034176048 hasConceptScore W3034176048C2779256446 @default.
• W3034176048 hasConceptScore W3034176048C2779473830 @default.
• W3034176048 hasConceptScore W3034176048C2779944601 @default.
• W3034176048 hasConceptScore W3034176048C3020000205 @default.
• W3034176048 hasConceptScore W3034176048C41008148 @default.
• W3034176048 hasConceptScore W3034176048C512399662 @default.
• W3034176048 hasConceptScore W3034176048C535046627 @default.
• W3034176048 hasConceptScore W3034176048C71924100 @default.
• W3034176048 hasConceptScore W3034176048C98274493 @default.
• W3034176048 hasLocation W30341760481 @default.
• W3034176048 hasLocation W30341760482 @default.
• W3034176048 hasLocation W30341760483 @default.
• W3034176048 hasLocation W30341760484 @default.
• W3034176048 hasOpenAccess W3034176048 @default.
• W3034176048 hasPrimaryLocation W30341760481 @default.
• W3034176048 hasRelatedWork W145088106 @default.
• W3034176048 hasRelatedWork W1996551696 @default.
• W3034176048 hasRelatedWork W2014529294 @default.
• W3034176048 hasRelatedWork W2076691999 @default.
• W3034176048 hasRelatedWork W2535064539 @default.
• W3034176048 hasRelatedWork W2596704481 @default.
• W3034176048 hasRelatedWork W3106529913 @default.
• W3034176048 hasRelatedWork W3143418575 @default.

• next