Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034202342> ?p ?o ?g. }
- W3034202342 endingPage "4150" @default.
- W3034202342 startingPage "4150" @default.
- W3034202342 abstract "The oral cavity of healthy individuals is inhabited by commensals, with species of Streptococcus being the most abundant and prevalent in sites not affected by periodontal diseases. The development of chronic periodontitis is linked with the environmental shift in the oral microbiome, leading to the domination of periodontopathogens. Structure-function studies showed that Streptococcus gordonii employs a “moonlighting” protein glyceraldehyde-3-phosphate dehydrogenase (SgGAPDH) to bind heme, thus forming a heme reservoir for exchange with other proteins. Secreted or surface-associated SgGAPDH coordinates Fe(III)heme using His43. Hemophore-like heme-binding proteins of Porphyromonas gingivalis (HmuY), Prevotella intermedia (PinO) and Tannerella forsythia (Tfo) sequester heme complexed to SgGAPDH. Co-culturing of P. gingivalis with S. gordonii results in increased hmuY gene expression, indicating that HmuY might be required for efficient inter-bacterial interactions. In contrast to the ΔhmuY mutant strain, the wild type strain acquires heme and forms deeper biofilm structures on blood agar plates pre-grown with S. gordonii. Therefore, our novel paradigm of heme acquisition used by P. gingivalis appears to extend to co-infections with other oral bacteria and offers a mechanism for the ability of periodontopathogens to obtain sufficient heme in the host environment. Importantly, P. gingivalis is advantaged in terms of acquiring heme, which is vital for its growth survival and virulence." @default.
- W3034202342 created "2020-06-19" @default.
- W3034202342 creator A5044938537 @default.
- W3034202342 creator A5055059245 @default.
- W3034202342 creator A5059022931 @default.
- W3034202342 creator A5082389527 @default.
- W3034202342 creator A5086095536 @default.
- W3034202342 date "2020-06-10" @default.
- W3034202342 modified "2023-10-15" @default.
- W3034202342 title "Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH—Novel Heme Acquisition Strategy in the Oral Microbiome" @default.
- W3034202342 cites W1565821928 @default.
- W3034202342 cites W1601982281 @default.
- W3034202342 cites W1730439168 @default.
- W3034202342 cites W1803102843 @default.
- W3034202342 cites W1937509760 @default.
- W3034202342 cites W1963827278 @default.
- W3034202342 cites W1966542721 @default.
- W3034202342 cites W1967490650 @default.
- W3034202342 cites W1972001117 @default.
- W3034202342 cites W1996634963 @default.
- W3034202342 cites W2000524912 @default.
- W3034202342 cites W2013531699 @default.
- W3034202342 cites W2015642465 @default.
- W3034202342 cites W2024634380 @default.
- W3034202342 cites W2040460416 @default.
- W3034202342 cites W2041089815 @default.
- W3034202342 cites W2043248182 @default.
- W3034202342 cites W2047808858 @default.
- W3034202342 cites W2054091129 @default.
- W3034202342 cites W2058226623 @default.
- W3034202342 cites W2060182219 @default.
- W3034202342 cites W2067129071 @default.
- W3034202342 cites W2072856387 @default.
- W3034202342 cites W2073077653 @default.
- W3034202342 cites W2073982406 @default.
- W3034202342 cites W2075572654 @default.
- W3034202342 cites W2077124327 @default.
- W3034202342 cites W2085082878 @default.
- W3034202342 cites W2088144539 @default.
- W3034202342 cites W2095913229 @default.
- W3034202342 cites W2103377606 @default.
- W3034202342 cites W2105876850 @default.
- W3034202342 cites W2111510085 @default.
- W3034202342 cites W2111637905 @default.
- W3034202342 cites W2118925320 @default.
- W3034202342 cites W2120502386 @default.
- W3034202342 cites W2121748291 @default.
- W3034202342 cites W2122301408 @default.
- W3034202342 cites W2126292601 @default.
- W3034202342 cites W2126470914 @default.
- W3034202342 cites W2126745151 @default.
- W3034202342 cites W2128300914 @default.
- W3034202342 cites W2130239469 @default.
- W3034202342 cites W2135727958 @default.
- W3034202342 cites W2136438408 @default.
- W3034202342 cites W2139915497 @default.
- W3034202342 cites W2143085675 @default.
- W3034202342 cites W2143996952 @default.
- W3034202342 cites W2147399606 @default.
- W3034202342 cites W2152544605 @default.
- W3034202342 cites W2153592812 @default.
- W3034202342 cites W2157107389 @default.
- W3034202342 cites W2162149255 @default.
- W3034202342 cites W2164091113 @default.
- W3034202342 cites W2169790852 @default.
- W3034202342 cites W2192030661 @default.
- W3034202342 cites W2252298505 @default.
- W3034202342 cites W2401626621 @default.
- W3034202342 cites W2405492410 @default.
- W3034202342 cites W2551364112 @default.
- W3034202342 cites W2593770639 @default.
- W3034202342 cites W2596987443 @default.
- W3034202342 cites W2623577695 @default.
- W3034202342 cites W2790271260 @default.
- W3034202342 cites W2792377429 @default.
- W3034202342 cites W2807011341 @default.
- W3034202342 cites W2883611877 @default.
- W3034202342 cites W2894413552 @default.
- W3034202342 cites W2912555658 @default.
- W3034202342 cites W2920933839 @default.
- W3034202342 cites W2949064059 @default.
- W3034202342 cites W2949871308 @default.
- W3034202342 cites W2952957890 @default.
- W3034202342 cites W2997532854 @default.
- W3034202342 cites W3003921680 @default.
- W3034202342 cites W4206545921 @default.
- W3034202342 cites W4241352628 @default.
- W3034202342 cites W2042397974 @default.
- W3034202342 doi "https://doi.org/10.3390/ijms21114150" @default.
- W3034202342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7312356" @default.
- W3034202342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32532033" @default.
- W3034202342 hasPublicationYear "2020" @default.
- W3034202342 type Work @default.
- W3034202342 sameAs 3034202342 @default.
- W3034202342 citedByCount "8" @default.
- W3034202342 countsByYear W30342023422020 @default.
- W3034202342 countsByYear W30342023422021 @default.
- W3034202342 countsByYear W30342023422022 @default.