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• W3034215145 abstract "Abstract Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sources utilizing immortalized NK cell lines require irradiation and are dependent on systemic IL-2 administration, which has been associated with adverse effects. In contrast, NK cells differentiated from induced pluripotent stem cells (iPSC-NK cells) offer an off-the-shelf alternative that may overcome these bottlenecks. The development of a serum-free and feeder-free differentiation protocol allows for the manufacturing of clinically adaptable iPSC-NK cells that are equally as effective as primary NK cells and the NK-92 cell line for many indications. Moreover, genetic modifications targeting NK-mediated antibody-dependent cellular cytotoxicity capabilities, cytotoxicity, and checkpoint inhibitors may increase the therapeutic potential of iPSC-NK products. This review will highlight the current sources for NK therapies and their respective constraints, discuss recent developments in the manufacturing and genetic engineering of iPSC-NK cells, and provide an overview of ongoing clinical trials using NK cells." @default.
• W3034215145 created "2020-06-19" @default.
• W3034215145 creator A5031469268 @default.
• W3034215145 creator A5056978851 @default.
• W3034215145 creator A5087358894 @default.
• W3034215145 date "2020-06-16" @default.
• W3034215145 modified "2023-10-14" @default.
• W3034215145 title "Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies" @default.
• W3034215145 cites W1571796034 @default.
• W3034215145 cites W1594345612 @default.
• W3034215145 cites W1671560425 @default.
• W3034215145 cites W1800095175 @default.
• W3034215145 cites W1939360714 @default.
• W3034215145 cites W1965119596 @default.
• W3034215145 cites W1966240013 @default.
• W3034215145 cites W1968475791 @default.
• W3034215145 cites W1969644995 @default.
• W3034215145 cites W1969950463 @default.
• W3034215145 cites W1972178991 @default.
• W3034215145 cites W1976911150 @default.
• W3034215145 cites W1981137720 @default.
• W3034215145 cites W1990416052 @default.
• W3034215145 cites W1991494425 @default.
• W3034215145 cites W1992908671 @default.
• W3034215145 cites W1993786192 @default.
• W3034215145 cites W1998007325 @default.
• W3034215145 cites W2002125829 @default.
• W3034215145 cites W2004201354 @default.
• W3034215145 cites W2009342562 @default.
• W3034215145 cites W2014349052 @default.
• W3034215145 cites W2016510876 @default.
• W3034215145 cites W2020313517 @default.
• W3034215145 cites W2020646453 @default.
• W3034215145 cites W2020709481 @default.
• W3034215145 cites W2035121417 @default.
• W3034215145 cites W2036088843 @default.
• W3034215145 cites W2039648189 @default.
• W3034215145 cites W2044103767 @default.
• W3034215145 cites W2045664257 @default.
• W3034215145 cites W2048273322 @default.
• W3034215145 cites W2051015958 @default.
• W3034215145 cites W2054154684 @default.
• W3034215145 cites W2056315817 @default.
• W3034215145 cites W2058522060 @default.
• W3034215145 cites W2059467769 @default.
• W3034215145 cites W2061385235 @default.
• W3034215145 cites W2061899375 @default.
• W3034215145 cites W2062504594 @default.
• W3034215145 cites W2064510700 @default.
• W3034215145 cites W2067814594 @default.
• W3034215145 cites W2068923616 @default.
• W3034215145 cites W2072015736 @default.
• W3034215145 cites W2072818859 @default.
• W3034215145 cites W2074583519 @default.
• W3034215145 cites W2076466010 @default.
• W3034215145 cites W2081047303 @default.
• W3034215145 cites W2087654677 @default.
• W3034215145 cites W2092166052 @default.
• W3034215145 cites W2096244608 @default.
• W3034215145 cites W2097050852 @default.
• W3034215145 cites W2098372175 @default.
• W3034215145 cites W2098394317 @default.
• W3034215145 cites W2098799914 @default.
• W3034215145 cites W2098930452 @default.
• W3034215145 cites W2101206430 @default.
• W3034215145 cites W2104016369 @default.
• W3034215145 cites W2104584195 @default.
• W3034215145 cites W2105557870 @default.
• W3034215145 cites W2112529511 @default.
• W3034215145 cites W2113811237 @default.
• W3034215145 cites W2115228434 @default.
• W3034215145 cites W2116553753 @default.
• W3034215145 cites W2118447882 @default.
• W3034215145 cites W2119607003 @default.
• W3034215145 cites W2122459559 @default.
• W3034215145 cites W2124416339 @default.
• W3034215145 cites W2124513722 @default.
• W3034215145 cites W2127022844 @default.
• W3034215145 cites W2137379725 @default.
• W3034215145 cites W2141502099 @default.
• W3034215145 cites W2141884708 @default.
• W3034215145 cites W2142125543 @default.
• W3034215145 cites W2144436556 @default.
• W3034215145 cites W2145794545 @default.
• W3034215145 cites W2147068163 @default.
• W3034215145 cites W2148239543 @default.
• W3034215145 cites W2151709130 @default.
• W3034215145 cites W2152596295 @default.
• W3034215145 cites W2154518608 @default.
• W3034215145 cites W2158469499 @default.
• W3034215145 cites W2158513713 @default.
• W3034215145 cites W2165635676 @default.
• W3034215145 cites W2165813814 @default.
• W3034215145 cites W2170069789 @default.
• W3034215145 cites W2211954339 @default.
• W3034215145 cites W2221432805 @default.
• W3034215145 cites W2227843001 @default.
• W3034215145 cites W2253944138 @default.
• W3034215145 cites W2298503769 @default.
• W3034215145 cites W2338392504 @default.

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