FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034228278> ?p ?o ?g. }

• W3034228278 abstract "Abstract Objective The assessment of clinical efficacy and toxicity is very important in pharmacology and toxicology. The effects of psychostimulants (e.g. amphetamine), psychotomimetics (e.g. Cannabis sativus) and snake antivenoms are sometimes unpredictable even at lower doses, leading to serious intoxication and fatal consequences. Hence, there is need to re-assess some formulas for calculation of therapeutic index, lethal time and safety margin with a view to identifying therapeutic agents with remarkable toxicity potentials. Results The therapeutic index formula $$left[ {T_{1} = 3left( {W_{a} times 10^{ - 4} } right)} right]$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mfenced> <mml:mrow> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mo>=</mml:mo> <mml:mn>3</mml:mn> <mml:mfenced> <mml:mrow> <mml:msub> <mml:mi>W</mml:mi> <mml:mi>a</mml:mi> </mml:msub> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>4</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:mfenced> </mml:mrow> </mml:mfenced> </mml:math> was derived from T 1 = LD 50 /ED 50 and ED 50 = $$frac{{LD_{50} }}{3} x W_{a} times 10^{ - 4}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mrow> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> <mml:mn>3</mml:mn> </mml:mfrac> <mml:mi>x</mml:mi> <mml:msub> <mml:mi>W</mml:mi> <mml:mi>a</mml:mi> </mml:msub> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>4</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> . Findings have shown that, therapeutic index is a function of death reversal (s), safety factor (10 −4 ) and weight of animal (Wa). However, the new safety margin formula $$left[ {MS = sqrt[3]{{frac{{LT_{50} }}{{LD_{50} }}}} times frac{1}{{ED_{99} }}} right]$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mfenced> <mml:mrow> <mml:mi>M</mml:mi> <mml:mi>S</mml:mi> <mml:mo>=</mml:mo> <mml:mroot> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> </mml:mfrac> <mml:mn>3</mml:mn> </mml:mroot> <mml:mo>×</mml:mo> <mml:mfrac> <mml:mn>1</mml:mn> <mml:mrow> <mml:mi>E</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>99</mml:mn> </mml:msub> </mml:mrow> </mml:mfrac> </mml:mrow> </mml:mfenced> </mml:math> derived from LT 50 = $$frac{{LD_{50} }}{{D_{1}^{p} }}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> <mml:msubsup> <mml:mi>D</mml:mi> <mml:mrow> <mml:mn>1</mml:mn> </mml:mrow> <mml:mi>p</mml:mi> </mml:msubsup> </mml:mfrac> </mml:math> and MS = $$frac{{LD_{1} }}{{ED_{99} }}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>1</mml:mn> </mml:msub> </mml:mrow> <mml:mrow> <mml:mi>E</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>99</mml:mn> </mml:msub> </mml:mrow> </mml:mfrac> </mml:math> shows that safety margin is a function of cube root of ratio between LT 50 and LD 50 and ED 100th . Concentration (k) of toxicant at the receptor $$left[ {K = sqrt[3]{{frac{{LT_{50} }}{{LD_{50} }}}} times frac{1}{{T^{n} }}} right]$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mfenced> <mml:mrow> <mml:mi>K</mml:mi> <mml:mo>=</mml:mo> <mml:mroot> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> </mml:mfrac> <mml:mn>3</mml:mn> </mml:mroot> <mml:mo>×</mml:mo> <mml:mfrac> <mml:mn>1</mml:mn> <mml:msup> <mml:mi>T</mml:mi> <mml:mi>n</mml:mi> </mml:msup> </mml:mfrac> </mml:mrow> </mml:mfenced> </mml:math> derived from D 1 × T n = K and LD 1 = $$sqrt[3]{{frac{{LT_{50} }}{{LD_{50} }}}}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mroot> <mml:mfrac> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>T</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> <mml:mrow> <mml:mi>L</mml:mi> <mml:msub> <mml:mi>D</mml:mi> <mml:mn>50</mml:mn> </mml:msub> </mml:mrow> </mml:mfrac> <mml:mn>3</mml:mn> </mml:mroot> </mml:math> shows that therapeutic index, lethal time and safety margin is a function of drug or toxicant concentration at the receptor, the drug-receptor interaction and dose of toxicant or drug administered at a particular time." @default.
• W3034228278 created "2020-06-19" @default.
• W3034228278 creator A5031816692 @default.
• W3034228278 date "2020-06-16" @default.
• W3034228278 modified "2023-10-14" @default.
• W3034228278 title "Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas" @default.
• W3034228278 cites W1566932432 @default.
• W3034228278 cites W1986088238 @default.
• W3034228278 cites W2017801261 @default.
• W3034228278 cites W2065796543 @default.
• W3034228278 cites W2074705230 @default.
• W3034228278 cites W2077002522 @default.
• W3034228278 cites W2091933980 @default.
• W3034228278 cites W2099259982 @default.
• W3034228278 cites W2145095988 @default.
• W3034228278 cites W2157837543 @default.
• W3034228278 cites W2314855317 @default.
• W3034228278 cites W2317867703 @default.
• W3034228278 cites W2319919593 @default.
• W3034228278 cites W2328323409 @default.
• W3034228278 cites W2497503399 @default.
• W3034228278 cites W2557234537 @default.
• W3034228278 cites W2605760497 @default.
• W3034228278 cites W2754565682 @default.
• W3034228278 cites W2773653190 @default.
• W3034228278 cites W2790644010 @default.
• W3034228278 cites W2800759064 @default.
• W3034228278 cites W2807828284 @default.
• W3034228278 cites W2894007837 @default.
• W3034228278 cites W2952125221 @default.
• W3034228278 cites W4211220845 @default.
• W3034228278 doi "https://doi.org/10.1186/s13104-020-05134-x" @default.
• W3034228278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7296648" @default.
• W3034228278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32546265" @default.
• W3034228278 hasPublicationYear "2020" @default.
• W3034228278 type Work @default.
• W3034228278 sameAs 3034228278 @default.
• W3034228278 citedByCount "5" @default.
• W3034228278 countsByYear W30342282782022 @default.
• W3034228278 crossrefType "journal-article" @default.
• W3034228278 hasAuthorship W3034228278A5031816692 @default.
• W3034228278 hasBestOaLocation W30342282781 @default.
• W3034228278 hasConcept C11413529 @default.
• W3034228278 hasConcept C41008148 @default.
• W3034228278 hasConceptScore W3034228278C11413529 @default.
• W3034228278 hasConceptScore W3034228278C41008148 @default.
• W3034228278 hasIssue "1" @default.
• W3034228278 hasLocation W30342282781 @default.
• W3034228278 hasLocation W30342282782 @default.
• W3034228278 hasLocation W30342282783 @default.
• W3034228278 hasLocation W30342282784 @default.
• W3034228278 hasOpenAccess W3034228278 @default.
• W3034228278 hasPrimaryLocation W30342282781 @default.
• W3034228278 hasRelatedWork W2051487156 @default.
• W3034228278 hasRelatedWork W2052122378 @default.
• W3034228278 hasRelatedWork W2053286651 @default.
• W3034228278 hasRelatedWork W2073681303 @default.
• W3034228278 hasRelatedWork W2317200988 @default.
• W3034228278 hasRelatedWork W2544423928 @default.
• W3034228278 hasRelatedWork W2947381795 @default.
• W3034228278 hasRelatedWork W2181413294 @default.
• W3034228278 hasRelatedWork W2181743346 @default.
• W3034228278 hasRelatedWork W2187401768 @default.
• W3034228278 hasVolume "13" @default.
• W3034228278 isParatext "false" @default.
• W3034228278 isRetracted "false" @default.
• W3034228278 magId "3034228278" @default.
• W3034228278 workType "article" @default.