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- W3034267612 abstract "Cutaneous squamous cell carcinoma (CSCC) is a common malignancy with an estimated incidence of 1,000,000 U.S. cases per year. A vast majority of tumors are cured with surgical removal, however, up to 4% of CSCCs will go on to develop metastasis to regional lymph nodes or distant sites. Current risk stratification is performed using clinical and histopathologic tumor information. The role of molecular expression testing is poorly established but may provide improved accuracy in prognostication as well as therapeutic insights. Using PubMed/MEDLINE and EMBASE, a systematic review was performed to identify and examine studies published between January 1st, 2005 and September 1st, 2019 that reported risk of metastasis or death from CSCC in humans with respect to tumor protein or RNA expression. An initial search yielded 436 records; 335 abstracts and 81 full text articles were screened and reviewed. Inclusion criteria were met by 45 studies containing 81 evaluations of 44 distinct proteins and 25 miRNAs. For analysis, studies results were divided into two categories: primary CSCCs tracked for poor outcomes (n=62, 2,267 subjects), and primary CSCC compared to metastatic tissue (n=19, 479 subjects). Significant results (p-value<0.05) of tumors tracked for poor outcomes were found in 50% (27/54) of evaluations reporting metastasis and 41% (12/29) reporting death. In evaluations comparing primary to metastatic tissue, 32% (6/19) detected significant differences in molecular expression. On pooled analysis, high expression of PD-L1 (OR 2.34, 95% CI 1.09-5.02, p=0.030), EGFR (OR 2.57, 95% CI 1.24-5.33, p=0.011) and podoplanin (OR 2.33, 95% CI 1.00- 5.41, p=0.049) conferred increased odds for metastasis. PD-L1 expression tissue differed between primary and metastatic tissue (OR 3.13, 95% CI 1.00-9.75, p=0.049). These results indicate further studies are needed to determine if immunohistochemical staining for PD-L1, EGFR, and podoplanin expression can aid in CSCC prognostic estimations and/or predict response to therapy." @default.
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- W3034267612 date "2020-07-01" @default.
- W3034267612 modified "2023-09-26" @default.
- W3034267612 title "112 Differential molecular expression patterns and risk for metastasis in cutaneous squamous cell carcinoma: A systematic review" @default.
- W3034267612 doi "https://doi.org/10.1016/j.jid.2020.03.115" @default.
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