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• W3034285217 abstract "Abstract Cancer is the second leading cause of mortality globally. Various nanoparticles have been developed to improve the efficacy and safety of chemotherapy, photothermal therapy, and their combination for treating cancer. However, most of the existing nanoparticles are low in both subcellular precision and drug loading content (<≈5%), and the effect of targeted heating of subcellular organelles on the enhancement of chemotherapy has not been well explored. Here, a hybrid Py@Si‐TH nanoparticle is reported to first target cancer cells overexpressed with the variant CD44 via its natural ligand HA on the outermost surface of the nanoparticle before cellular uptake, and then target mitochondria after they are taken up inside cells. In addition, the nanoparticle is ultraefficient for encapsulating doxorubicin hydrochloride (DOX) to form Py@Si‐TH‐DOX nanoparticle. The encapsulation efficiency is ≈100% at the commonly used low feeding ratio of 1:20 (DOX:empty nanoparticle), and >80% at an ultrahigh feeding ratio of 1:1. In combination with near infrared (NIR, 808 nm) laser irradiation, the tumor weight in the Py@Si‐TH‐DOX treatment group is 8.5 times less than that in the Py@Si‐H‐DOX (i.e., DOX‐laden nanoparticles without mitochondrial targeting) group, suggesting targeted heating of mitochondria is a valuable strategy for enhancing chemotherapy to combat cancer." @default.
• W3034285217 created "2020-06-19" @default.
• W3034285217 creator A5001644143 @default.
• W3034285217 creator A5021686580 @default.
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• W3034285217 creator A5088319695 @default.
• W3034285217 date "2020-06-17" @default.
• W3034285217 modified "2023-10-14" @default.
• W3034285217 title "Targeted Heating of Mitochondria Greatly Augments Nanoparticle‐Mediated Cancer Chemotherapy" @default.
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• W3034285217 doi "https://doi.org/10.1002/adhm.202000181" @default.
• W3034285217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7879459" @default.
• W3034285217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32548935" @default.
• W3034285217 hasPublicationYear "2020" @default.
• W3034285217 type Work @default.
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• W3034285217 hasAuthorship W3034285217A5001644143 @default.
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