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- W3034291203 endingPage "116625" @default.
- W3034291203 startingPage "116625" @default.
- W3034291203 abstract "Bacterial cellulose (BC) is recognized as a wound dressing material well-suited for chronic wounds; however, it has no intrinsic antimicrobial activity. Further, the formation of biofilms can limit the effectiveness of the pre-saturation of BC with antimicrobial agents. Here, to hinder biofilm formation by P. aeruginosa, we immobilized the hydrolytic domain of PelA (a glycohydrolase involved in the synthesis of biofilm polysaccharide Pel) on the surface of BC. The immobilization of 32.35 ± 1.05 mg PelAh per g BC membrane resulted in an eight-fold higher P. aeruginosa cell detachment from BC membrane, indicating reduced biofilm matrix stability. Further, 1D and 2D infrared spectroscopy analysis indicated systematic reduction of polysaccharide biofilm elements, confirming the specificity of immobilized PelAh. Importantly, BC-PelAh was not cytotoxic towards L929 fibroblast cells. Thus, we conclude that PelAh can be used in BC wound dressings for safe and specific protection against biofilm formation by P. aeruginosa." @default.
- W3034291203 created "2020-06-19" @default.
- W3034291203 creator A5009684240 @default.
- W3034291203 creator A5041016320 @default.
- W3034291203 creator A5055216285 @default.
- W3034291203 creator A5063040271 @default.
- W3034291203 creator A5072814114 @default.
- W3034291203 creator A5075445141 @default.
- W3034291203 creator A5079472462 @default.
- W3034291203 creator A5087192700 @default.
- W3034291203 date "2020-10-01" @default.
- W3034291203 modified "2023-10-18" @default.
- W3034291203 title "Glycoside hydrolase (PelAh) immobilization prevents Pseudomonas aeruginosa biofilm formation on cellulose-based wound dressing" @default.
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