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• W3034296856 abstract "Abstract Recent advances in T cell repertoire (TCR) sequencing allow for characterization of repertoire properties, as well as the frequency and sharing of specific TCR. However, there is no efficient measure for the local density of a given TCR. TCRs are often described either through their Complementary Determining region 3 (CDR3) sequences, or theirV/J usage or their clone size. We here show that the local repertoire density can be estimated using a combined representation of these components through distance conserving autoencoders and Kernel Density Estimates (KDE). We present ELATE – an Encoder based LocAl Tcr dEnsity and show that the resulting density of a sample can be used as a novel measure to study repertoire properties. The cross-density between two samples can be used as a similarity matrix to fully characterize samples from the same host. Finally, the same projection in combination with machine learning algorithms can be used to predict TCR-peptide binding through the local density of known TCRs binding a specific target. Code availability- https://github.com/louzounlab/Autoencoder" @default.
• W3034296856 created "2020-06-19" @default.
• W3034296856 creator A5062799734 @default.
• W3034296856 creator A5083239943 @default.
• W3034296856 date "2020-06-12" @default.
• W3034296856 modified "2023-10-18" @default.
• W3034296856 title "Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors" @default.
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• W3034296856 doi "https://doi.org/10.1101/2020.06.12.148502" @default.
• W3034296856 hasPublicationYear "2020" @default.
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