FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034309905> ?p ?o ?g. }

• W3034309905 endingPage "1843" @default.
• W3034309905 startingPage "1843" @default.
• W3034309905 abstract "Asymmetric protein-arginine dimethylation is a major post-translational modification (PTM) catalyzed by protein-arginine methyltransferase (PRMT). Regular proteolysis releases asymmetric dimethylarginine (ADMA). Of the daily produced ADMA, about 10% are excreted unchanged in the urine. The remaining 90% are hydrolyzed by dimethylarginine dimethylaminohydrolase (DDAH) to L-citrulline and dimethylamine (DMA), which is readily excreted in the urine. The PRMT/DDAH pathway is almost the exclusive origin of urinary ADMA and the major source of urinary DMA. Dietary fish and seafood represent additional abundant sources of urinary DMA. The present article provides an overview of urinary ADMA and DMA reported thus far in epidemiological, clinical and pharmacological studies, in connection with the L-arginine/nitric oxide (NO) pathway and beyond, in neonates, children and adolescents, young and elderly subjects, males and females. Discussed diseases mainly include those relating to the renal and cardiovascular systems such as peripheral arterial occlusive disease, coronary artery disease, chronic kidney disease, rheumatoid arthritis, Becker muscular disease, Duchenne muscular disease (DMD), attention deficit hyperactivity disorder (ADHD), and type I diabetes. Under standardized conditions involving the abstinence of DMA-rich fresh and canned fish and seafood, urinary DMA and ADMA are useful as measures of whole-body asymmetric arginine-dimethylation in health and disease. The creatinine-corrected excretion rates of DMA range from 10 to 80 µmol/mmol in adults and up to 400 µmol/mmol in children and adolescents. The creatinine-corrected excretion rates of ADMA are on average 10 times lower. In general, diseases are associated with higher urinary DMA and ADMA excretion rates, and pharmacological treatment, such as with steroids and creatine (in DMD), decreases their excretion rates, which may be accompanied by a decreased urinary excretion of nitrate, the major metabolite of NO. In healthy subjects and in rheumatoid arthritis patients, the urinary excretion rate of DMA correlates positively with the excretion rate of dihydroxyphenylglycol (DHPG), the major urinary catecholamines metabolite, suggesting a potential interplay in the PRMT/DDAH/NO pathway." @default.
• W3034309905 created "2020-06-19" @default.
• W3034309905 creator A5044012246 @default.
• W3034309905 date "2020-06-12" @default.
• W3034309905 modified "2023-10-14" @default.
• W3034309905 title "Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond" @default.
• W3034309905 cites W1507016459 @default.
• W3034309905 cites W1879555632 @default.
• W3034309905 cites W1898920249 @default.
• W3034309905 cites W1908353230 @default.
• W3034309905 cites W1964338902 @default.
• W3034309905 cites W1969617719 @default.
• W3034309905 cites W1975521806 @default.
• W3034309905 cites W1984282483 @default.
• W3034309905 cites W1985747103 @default.
• W3034309905 cites W1987443027 @default.
• W3034309905 cites W1988534299 @default.
• W3034309905 cites W1992015303 @default.
• W3034309905 cites W2001359030 @default.
• W3034309905 cites W2003196001 @default.
• W3034309905 cites W2003405826 @default.
• W3034309905 cites W2003602985 @default.
• W3034309905 cites W2004384480 @default.
• W3034309905 cites W2009022649 @default.
• W3034309905 cites W2011849277 @default.
• W3034309905 cites W2013443032 @default.
• W3034309905 cites W2018959075 @default.
• W3034309905 cites W2019074989 @default.
• W3034309905 cites W2019777849 @default.
• W3034309905 cites W2030070089 @default.
• W3034309905 cites W2035344879 @default.
• W3034309905 cites W2042102415 @default.
• W3034309905 cites W2046750893 @default.
• W3034309905 cites W2065374983 @default.
• W3034309905 cites W2066719628 @default.
• W3034309905 cites W2067251916 @default.
• W3034309905 cites W2072230060 @default.
• W3034309905 cites W2072556756 @default.
• W3034309905 cites W2072950261 @default.
• W3034309905 cites W2076452226 @default.
• W3034309905 cites W2076988231 @default.
• W3034309905 cites W2084256027 @default.
• W3034309905 cites W2087311814 @default.
• W3034309905 cites W2089850561 @default.
• W3034309905 cites W2090170448 @default.
• W3034309905 cites W2092825572 @default.
• W3034309905 cites W2094305633 @default.
• W3034309905 cites W2106535141 @default.
• W3034309905 cites W2113607745 @default.
• W3034309905 cites W2131177304 @default.
• W3034309905 cites W2134974345 @default.
• W3034309905 cites W2145183598 @default.
• W3034309905 cites W2153081833 @default.
• W3034309905 cites W2153411231 @default.
• W3034309905 cites W2165753570 @default.
• W3034309905 cites W2166937516 @default.
• W3034309905 cites W2178116648 @default.
• W3034309905 cites W2205426272 @default.
• W3034309905 cites W2236245555 @default.
• W3034309905 cites W2278044581 @default.
• W3034309905 cites W2291969078 @default.
• W3034309905 cites W2410675161 @default.
• W3034309905 cites W2417318317 @default.
• W3034309905 cites W2463194462 @default.
• W3034309905 cites W2533986239 @default.
• W3034309905 cites W2561173573 @default.
• W3034309905 cites W2562881395 @default.
• W3034309905 cites W2570732803 @default.
• W3034309905 cites W2583097405 @default.
• W3034309905 cites W2593341591 @default.
• W3034309905 cites W2596000058 @default.
• W3034309905 cites W2610326627 @default.
• W3034309905 cites W2734603604 @default.
• W3034309905 cites W2737694881 @default.
• W3034309905 cites W2781933653 @default.
• W3034309905 cites W2801977840 @default.
• W3034309905 cites W2832233152 @default.
• W3034309905 cites W2905287798 @default.
• W3034309905 cites W2954910577 @default.
• W3034309905 cites W2998840683 @default.
• W3034309905 cites W3001824696 @default.
• W3034309905 cites W3006741375 @default.
• W3034309905 cites W3010281575 @default.
• W3034309905 cites W3011222751 @default.
• W3034309905 cites W3026882458 @default.
• W3034309905 cites W821670459 @default.
• W3034309905 cites W2070028015 @default.
• W3034309905 doi "https://doi.org/10.3390/jcm9061843" @default.
• W3034309905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7356952" @default.
• W3034309905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32545708" @default.
• W3034309905 hasPublicationYear "2020" @default.
• W3034309905 type Work @default.
• W3034309905 sameAs 3034309905 @default.
• W3034309905 citedByCount "24" @default.
• W3034309905 countsByYear W30343099052020 @default.
• W3034309905 countsByYear W30343099052021 @default.
• W3034309905 countsByYear W30343099052022 @default.
• W3034309905 countsByYear W30343099052023 @default.

• next