FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034332220> ?p ?o ?g. }

• W3034332220 endingPage "18" @default.
• W3034332220 startingPage "13" @default.
• W3034332220 abstract "Postoperative cognitive dysfunction (POCD) is a complication of central nervous system in patients after surgery. Edaravone as a brain-protective agent may have protective effect on postoperative cognitive function. The study was designed to explore the effects of edaravone on postoperative cognitive function in elderly patients undergoing hip joint replacement surgery and potential mechanism. Patients undergoing hip joint replacement surgery were randomly allocated into 2 groups: the edaravone group (group E) and the control group (group C). Group E received intravenous edaravone at a dose of 0.5 mg/kg after induction of anesthesia, while group C received normal saline. The cognitive function was evaluated with the Mini-Mental State Examination (MMSE) 1day before surgery,3 days and the 7 days after surgery. Patients’ plasma samples were collected to detect the levels of S100β protein (S100β), interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), superoxide dismutase (SOD) and malondialdehyde (MDA) before the induction of anesthesia, at the end of surgery and on postoperative day 3. The MMSE scores in group E were higher than those of group C 3 days after surgery (25.98 ± 1.99 vs 24.86 ± 1.86, p = 0.003). There were remarkable rises ( p < 0.05) in plasma IL-6, S100βand MMP-9 levels at the end of surgery and on postoperative day 3 in the two groups, however, edaravone pretreatment could reduce these levels to a certain extent compared with group C ( p < 0.05).In group E, the SOD concentration was higher at the end of surgery (16.03 ± 2.46U/ml vs. 13.65 ± 2.53U/ml, p = 0.0001), while the MDA level was lower on postoperative day 3 than those in group C (7.01 ± 2.37 nmol/ml vs. 11.34 ± 3.18 nmol/ml, p = 0.0001). The results indicated that preoperative intervention with edaravone may improve the postoperative cognitive function in elderly patients undergoing hip joint replacement surgery. • Edaravone, which is commonly used in neurology, is innovatively applied in anesthesiology in this study. • Edaravone has cognitive protective property after operation. • Edaravone can decrease the levels of interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9).Edaravone can upregulate superoxide dismutase (SOD) level in plasma in elderly surgery patients. • Edaravone can upregulate superoxide dismutase (SOD) level in plasma in elderly surgery patients." @default.
• W3034332220 created "2020-06-19" @default.
• W3034332220 creator A5002593519 @default.
• W3034332220 creator A5009784397 @default.
• W3034332220 creator A5018764940 @default.
• W3034332220 creator A5026019509 @default.
• W3034332220 creator A5036771549 @default.
• W3034332220 date "2020-08-01" @default.
• W3034332220 modified "2023-10-06" @default.
• W3034332220 title "Effects of edaravone on postoperative cognitive function in elderly patients undergoing hip joint replacement surgery: A randomized controlled trial" @default.
• W3034332220 cites W195100871 @default.
• W3034332220 cites W1971878152 @default.
• W3034332220 cites W1978064961 @default.
• W3034332220 cites W1981665503 @default.
• W3034332220 cites W1989369404 @default.
• W3034332220 cites W1992227603 @default.
• W3034332220 cites W2018096181 @default.
• W3034332220 cites W2032291936 @default.
• W3034332220 cites W2035703958 @default.
• W3034332220 cites W2036834828 @default.
• W3034332220 cites W2061127494 @default.
• W3034332220 cites W2062485660 @default.
• W3034332220 cites W2072130574 @default.
• W3034332220 cites W2083990390 @default.
• W3034332220 cites W2087357049 @default.
• W3034332220 cites W2090514944 @default.
• W3034332220 cites W2103617734 @default.
• W3034332220 cites W2108429535 @default.
• W3034332220 cites W2135735522 @default.
• W3034332220 cites W2147003577 @default.
• W3034332220 cites W2149615621 @default.
• W3034332220 cites W2154915166 @default.
• W3034332220 cites W2162055755 @default.
• W3034332220 cites W2163862018 @default.
• W3034332220 cites W2192064898 @default.
• W3034332220 cites W2235896510 @default.
• W3034332220 cites W2512128069 @default.
• W3034332220 cites W2910169348 @default.
• W3034332220 doi "https://doi.org/10.1016/j.ijsu.2020.05.092" @default.
• W3034332220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32535263" @default.
• W3034332220 hasPublicationYear "2020" @default.
• W3034332220 type Work @default.
• W3034332220 sameAs 3034332220 @default.
• W3034332220 citedByCount "13" @default.
• W3034332220 countsByYear W30343322202020 @default.
• W3034332220 countsByYear W30343322202021 @default.
• W3034332220 countsByYear W30343322202022 @default.
• W3034332220 countsByYear W30343322202023 @default.
• W3034332220 crossrefType "journal-article" @default.
• W3034332220 hasAuthorship W3034332220A5002593519 @default.
• W3034332220 hasAuthorship W3034332220A5009784397 @default.
• W3034332220 hasAuthorship W3034332220A5018764940 @default.
• W3034332220 hasAuthorship W3034332220A5026019509 @default.
• W3034332220 hasAuthorship W3034332220A5036771549 @default.
• W3034332220 hasBestOaLocation W30343322201 @default.
• W3034332220 hasConcept C118552586 @default.
• W3034332220 hasConcept C141071460 @default.
• W3034332220 hasConcept C168563851 @default.
• W3034332220 hasConcept C169900460 @default.
• W3034332220 hasConcept C2778336525 @default.
• W3034332220 hasConcept C2779554857 @default.
• W3034332220 hasConcept C2992051495 @default.
• W3034332220 hasConcept C42219234 @default.
• W3034332220 hasConcept C71924100 @default.
• W3034332220 hasConceptScore W3034332220C118552586 @default.
• W3034332220 hasConceptScore W3034332220C141071460 @default.
• W3034332220 hasConceptScore W3034332220C168563851 @default.
• W3034332220 hasConceptScore W3034332220C169900460 @default.
• W3034332220 hasConceptScore W3034332220C2778336525 @default.
• W3034332220 hasConceptScore W3034332220C2779554857 @default.
• W3034332220 hasConceptScore W3034332220C2992051495 @default.
• W3034332220 hasConceptScore W3034332220C42219234 @default.
• W3034332220 hasConceptScore W3034332220C71924100 @default.
• W3034332220 hasFunder F4320321001 @default.
• W3034332220 hasLocation W30343322201 @default.
• W3034332220 hasOpenAccess W3034332220 @default.
• W3034332220 hasPrimaryLocation W30343322201 @default.
• W3034332220 hasRelatedWork W2002120878 @default.
• W3034332220 hasRelatedWork W2003938723 @default.
• W3034332220 hasRelatedWork W2047967234 @default.
• W3034332220 hasRelatedWork W2118496982 @default.
• W3034332220 hasRelatedWork W2364998975 @default.
• W3034332220 hasRelatedWork W2439875401 @default.
• W3034332220 hasRelatedWork W2441962935 @default.
• W3034332220 hasRelatedWork W3034332220 @default.
• W3034332220 hasRelatedWork W4238867864 @default.
• W3034332220 hasRelatedWork W2525756941 @default.
• W3034332220 hasVolume "80" @default.
• W3034332220 isParatext "false" @default.
• W3034332220 isRetracted "false" @default.
• W3034332220 magId "3034332220" @default.
• W3034332220 workType "article" @default.