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• W3034334414 abstract "Herbal medicine containing aristolochic acids (HMCAA) was used for inflammatory and infectious diseases. This study aimed to investigate the association between the usage of HMCAA and the risk of dementia.A total of 199 new users of HMCAA were enrolled, along with 597 controls without the usage of HMCAA, at a ratio of 1:3 - matched by age, sex, and comorbidity, between 2000 and 2003 - from the National Health Research Institutes Database (NHRID) of Taiwan, which contains two million randomly sampled subjects, in this cohort study. We used Fine and Gray's survival analysis (competing with mortality) to compare the risk of developing dementia during a 15-year follow-up period (2000-2015).In general, HMCAA was not significantly associated with dementia (adjusted subdistribution hazard ratio [SHR] = 0.861, 95% confidence interval [CI] = 0.484-1.532, p = 0.611) for the HMCAA-cohort, although differential risk was observed among the groups at risk. The patients with usage of HMCAA aged ≧ 85 years were associated with a higher risk in dementia (adjusted SHR: 6.243, 95% CI=1.258-21.084, p = 0.001), in comparison to those aged 50-54 years. Furthermore, the patients with usage of HMCAA that had cerebrovascular accidents were associated with an increased risk of dementia.The usage of HMCAA was associated with the risk of developing dementia in the patients aged ≧ 85 years." @default.
• W3034334414 created "2020-06-19" @default.
• W3034334414 creator A5002843807 @default.
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• W3034334414 date "2020-06-01" @default.
• W3034334414 modified "2023-10-16" @default.
• W3034334414 title "<p>New Users of Herbal Medicine Containing Aristolochic Acids and the Risk of Dementia in the Elderly: A Nationwide, Population-Based Study in Taiwan</p>" @default.
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• W3034334414 doi "https://doi.org/10.2147/ndt.s250659" @default.
• W3034334414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7297452" @default.
• W3034334414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32606702" @default.
• W3034334414 hasPublicationYear "2020" @default.
• W3034334414 type Work @default.
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