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• W3034335701 startingPage "111282" @default.
• W3034335701 abstract "Ribosome biogenesis takes place mainly in the nucleolus, a nuclear, non-membrane bound organelle forming around the gene arrays encoding ribosomal RNA (rRNA). Nucleolar activity comprises synthesis, processing and maturation of rRNAs, followed by their assembly with ribosomal proteins into pre-ribosomal particles. The final formation of translation-competent ribosomes in the cytoplasm is the prerequisite for protein synthesis, which is the most energy-consuming cellular process. In adult stem cells, ribosome biogenesis and protein synthesis determine the switch between the quiescent and the activated state, but also decide whether activated stem cells self-renew or differentiate. Given this major impact on cellular function, it seems likely that perturbations of the circuitry between nucleolar activity and translation lead to ageing-related stem cell deterioration. This review provides an overview of how ribosome biogenesis and translation govern stem cell function and discusses the resultant implication in stem cell ageing." @default.
• W3034335701 created "2020-06-19" @default.
• W3034335701 creator A5017997089 @default.
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• W3034335701 date "2020-07-01" @default.
• W3034335701 modified "2023-10-17" @default.
• W3034335701 title "The circuitry between ribosome biogenesis and translation in stem cell function and ageing" @default.
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• W3034335701 doi "https://doi.org/10.1016/j.mad.2020.111282" @default.
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• W3034335701 hasPublicationYear "2020" @default.
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