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- W3034364980 abstract "Abstract Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to the use of non‐degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near‐infrared (NIR)‐irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)‐ b ‐poly( d,l ‐lactide) (PEG‐PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphology allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10 μm s −1 . These polymersome nanomotors (PNMs) are capable of traversing cellular membranes allowing intracellular delivery of molecular and macromolecular cargo." @default.
- W3034364980 created "2020-06-19" @default.
- W3034364980 creator A5016240985 @default.
- W3034364980 creator A5016767643 @default.
- W3034364980 creator A5029495077 @default.
- W3034364980 creator A5039338084 @default.
- W3034364980 creator A5046764814 @default.
- W3034364980 date "2020-07-27" @default.
- W3034364980 modified "2023-10-15" @default.
- W3034364980 title "Photoactivated Polymersome Nanomotors: Traversing Biological Barriers" @default.
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