FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034372272> ?p ?o ?g. }

• W3034372272 endingPage "1772" @default.
• W3034372272 startingPage "1765" @default.
• W3034372272 abstract "Dinucleoside polyphosphates (NpnNs) were discovered 50 years ago in all cells. They are often called alarmones, even though the molecular target of the alarm has not yet been identified. Recently, we showed that they serve as noncanonical initiating nucleotides (NCINs) and fulfill the role of 5′ RNA caps in Escherichia coli. Here, we present molecular insight into their ability to be used as NCINs by T7 RNA polymerase in the initiation phase of transcription. In general, we observed NpnNs to be equally good substrates as canonical nucleotides for T7 RNA polymerase. Surprisingly, the incorporation of ApnGs boosts the production of RNA 10-fold. This behavior is due to the pairing ability of both purine moieties with the −1 and +1 positions of the antisense DNA strand. Molecular dynamic simulations revealed noncanonical pairing of adenosine with the thymine of the DNA." @default.
• W3034372272 created "2020-06-19" @default.
• W3034372272 creator A5017785180 @default.
• W3034372272 creator A5027022319 @default.
• W3034372272 creator A5044682280 @default.
• W3034372272 creator A5069493142 @default.
• W3034372272 creator A5069659475 @default.
• W3034372272 date "2020-06-12" @default.
• W3034372272 modified "2023-09-30" @default.
• W3034372272 title "Dinucleoside Polyphosphates as RNA Building Blocks with Pairing Ability in Transcription Initiation" @default.
• W3034372272 cites W1985114988 @default.
• W3034372272 cites W1987147367 @default.
• W3034372272 cites W2026724911 @default.
• W3034372272 cites W2031388575 @default.
• W3034372272 cites W2057862944 @default.
• W3034372272 cites W2078964320 @default.
• W3034372272 cites W2168260857 @default.
• W3034372272 cites W2170540925 @default.
• W3034372272 cites W2319287254 @default.
• W3034372272 cites W2469961971 @default.
• W3034372272 cites W2561816730 @default.
• W3034372272 cites W2564621176 @default.
• W3034372272 cites W2590034108 @default.
• W3034372272 cites W2594338651 @default.
• W3034372272 cites W2766140892 @default.
• W3034372272 cites W2911349862 @default.
• W3034372272 cites W2915489297 @default.
• W3034372272 cites W2917141151 @default.
• W3034372272 cites W2949648903 @default.
• W3034372272 cites W2971597931 @default.
• W3034372272 cites W2997488647 @default.
• W3034372272 cites W2998556276 @default.
• W3034372272 cites W3004398293 @default.
• W3034372272 cites W3004728918 @default.
• W3034372272 cites W3007126735 @default.
• W3034372272 doi "https://doi.org/10.1021/acschembio.0c00178" @default.
• W3034372272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32530599" @default.
• W3034372272 hasPublicationYear "2020" @default.
• W3034372272 type Work @default.
• W3034372272 sameAs 3034372272 @default.
• W3034372272 citedByCount "7" @default.
• W3034372272 countsByYear W30343722722020 @default.
• W3034372272 countsByYear W30343722722021 @default.
• W3034372272 countsByYear W30343722722022 @default.
• W3034372272 crossrefType "journal-article" @default.
• W3034372272 hasAuthorship W3034372272A5017785180 @default.
• W3034372272 hasAuthorship W3034372272A5027022319 @default.
• W3034372272 hasAuthorship W3034372272A5044682280 @default.
• W3034372272 hasAuthorship W3034372272A5069493142 @default.
• W3034372272 hasAuthorship W3034372272A5069659475 @default.
• W3034372272 hasBestOaLocation W30343722721 @default.
• W3034372272 hasConcept C101762097 @default.
• W3034372272 hasConcept C104317684 @default.
• W3034372272 hasConcept C138885662 @default.
• W3034372272 hasConcept C150194340 @default.
• W3034372272 hasConcept C153911025 @default.
• W3034372272 hasConcept C179926584 @default.
• W3034372272 hasConcept C185592680 @default.
• W3034372272 hasConcept C21786251 @default.
• W3034372272 hasConcept C24107716 @default.
• W3034372272 hasConcept C2776441376 @default.
• W3034372272 hasConcept C2776449523 @default.
• W3034372272 hasConcept C2780048736 @default.
• W3034372272 hasConcept C41258723 @default.
• W3034372272 hasConcept C41895202 @default.
• W3034372272 hasConcept C512185932 @default.
• W3034372272 hasConcept C54355233 @default.
• W3034372272 hasConcept C547475151 @default.
• W3034372272 hasConcept C552990157 @default.
• W3034372272 hasConcept C55493867 @default.
• W3034372272 hasConcept C64350747 @default.
• W3034372272 hasConcept C67705224 @default.
• W3034372272 hasConcept C82381507 @default.
• W3034372272 hasConcept C86803240 @default.
• W3034372272 hasConcept C95444343 @default.
• W3034372272 hasConceptScore W3034372272C101762097 @default.
• W3034372272 hasConceptScore W3034372272C104317684 @default.
• W3034372272 hasConceptScore W3034372272C138885662 @default.
• W3034372272 hasConceptScore W3034372272C150194340 @default.
• W3034372272 hasConceptScore W3034372272C153911025 @default.
• W3034372272 hasConceptScore W3034372272C179926584 @default.
• W3034372272 hasConceptScore W3034372272C185592680 @default.
• W3034372272 hasConceptScore W3034372272C21786251 @default.
• W3034372272 hasConceptScore W3034372272C24107716 @default.
• W3034372272 hasConceptScore W3034372272C2776441376 @default.
• W3034372272 hasConceptScore W3034372272C2776449523 @default.
• W3034372272 hasConceptScore W3034372272C2780048736 @default.
• W3034372272 hasConceptScore W3034372272C41258723 @default.
• W3034372272 hasConceptScore W3034372272C41895202 @default.
• W3034372272 hasConceptScore W3034372272C512185932 @default.
• W3034372272 hasConceptScore W3034372272C54355233 @default.
• W3034372272 hasConceptScore W3034372272C547475151 @default.
• W3034372272 hasConceptScore W3034372272C552990157 @default.
• W3034372272 hasConceptScore W3034372272C55493867 @default.
• W3034372272 hasConceptScore W3034372272C64350747 @default.
• W3034372272 hasConceptScore W3034372272C67705224 @default.
• W3034372272 hasConceptScore W3034372272C82381507 @default.
• W3034372272 hasConceptScore W3034372272C86803240 @default.

• next