Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034377897> ?p ?o ?g. }
- W3034377897 endingPage "1796" @default.
- W3034377897 startingPage "1796" @default.
- W3034377897 abstract "Inflammatory bowel disease (IBD) is known to significantly increase the risk for development of colorectal cancer (CRC), suggesting inflammation and cancer development are closely intertwined. Thus, agents that suppress inflammation may prevent the onset of cancer. In the current study, we used resveratrol, an anti-inflammatory stilbenoid, to study the role of microbiota in preventing inflammation-driven CRC. Resveratrol treatment in the azoxymethane (AOM) and dextran sodium sulphate (DSS) CRC murine model caused an increase in anti-inflammatory CD4 + FOXP3 + (Tregs) and CD4 + IL10 + cells, a decrease in proinflammatory Th1 and Th17 cells, and attenuated CRC development. Gut microbial profile studies demonstrated that resveratrol altered the gut microbiome and short chain fatty acid (SCFA), with modest increases in n-butyric acid and a potential butyrate precursor isobutyric acid. Fecal transfer from resveratrol-treated CRC mice and butyrate supplementation resulted in attenuation of disease and suppression of the inflammatory T cell response. Data also revealed both resveratrol and sodium butyrate (BUT) were capable of inhibiting histone deacetylases (HDACs), correlating with Treg induction. Analysis of The Cancer Genome Atlas (TCGA) datasets revealed increased expression of Treg-specific transcription factor FoxP3 or anti-inflammatory IL-10 resulted in an increase in 5-year survival of patients with CRC. These data suggest that alterations in the gut microbiome lead to an anti-inflammatory T cell response, leading to attenuation of inflammation-driven CRC." @default.
- W3034377897 created "2020-06-19" @default.
- W3034377897 creator A5015324418 @default.
- W3034377897 creator A5027226572 @default.
- W3034377897 creator A5046315471 @default.
- W3034377897 creator A5053934108 @default.
- W3034377897 creator A5061239650 @default.
- W3034377897 date "2020-06-09" @default.
- W3034377897 modified "2023-10-16" @default.
- W3034377897 title "Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer" @default.
- W3034377897 cites W1484825455 @default.
- W3034377897 cites W1536121021 @default.
- W3034377897 cites W1820665885 @default.
- W3034377897 cites W1888445862 @default.
- W3034377897 cites W190201149 @default.
- W3034377897 cites W1969252619 @default.
- W3034377897 cites W1974525446 @default.
- W3034377897 cites W1983079992 @default.
- W3034377897 cites W1986386190 @default.
- W3034377897 cites W1996812938 @default.
- W3034377897 cites W2000647244 @default.
- W3034377897 cites W2003342633 @default.
- W3034377897 cites W2035490264 @default.
- W3034377897 cites W2062372651 @default.
- W3034377897 cites W2062567955 @default.
- W3034377897 cites W2064500523 @default.
- W3034377897 cites W2089246633 @default.
- W3034377897 cites W2107053205 @default.
- W3034377897 cites W2110300022 @default.
- W3034377897 cites W2123158481 @default.
- W3034377897 cites W2133856765 @default.
- W3034377897 cites W2134140786 @default.
- W3034377897 cites W2139205910 @default.
- W3034377897 cites W2143728413 @default.
- W3034377897 cites W2148287035 @default.
- W3034377897 cites W2148709635 @default.
- W3034377897 cites W2151683706 @default.
- W3034377897 cites W2155939414 @default.
- W3034377897 cites W2164272712 @default.
- W3034377897 cites W2170970016 @default.
- W3034377897 cites W2231729745 @default.
- W3034377897 cites W2265770493 @default.
- W3034377897 cites W2267145743 @default.
- W3034377897 cites W2324161694 @default.
- W3034377897 cites W2344741754 @default.
- W3034377897 cites W2503545256 @default.
- W3034377897 cites W2514075044 @default.
- W3034377897 cites W2522526868 @default.
- W3034377897 cites W2529049144 @default.
- W3034377897 cites W2606481429 @default.
- W3034377897 cites W2612412789 @default.
- W3034377897 cites W2618430068 @default.
- W3034377897 cites W2620249061 @default.
- W3034377897 cites W2620494983 @default.
- W3034377897 cites W2735740095 @default.
- W3034377897 cites W2735925508 @default.
- W3034377897 cites W2745156487 @default.
- W3034377897 cites W2746788320 @default.
- W3034377897 cites W2749700969 @default.
- W3034377897 cites W2758274666 @default.
- W3034377897 cites W2760007656 @default.
- W3034377897 cites W2760290205 @default.
- W3034377897 cites W2762107171 @default.
- W3034377897 cites W2762873639 @default.
- W3034377897 cites W2763151664 @default.
- W3034377897 cites W2765113361 @default.
- W3034377897 cites W2765664791 @default.
- W3034377897 cites W2766230324 @default.
- W3034377897 cites W2769686961 @default.
- W3034377897 cites W2771136768 @default.
- W3034377897 cites W2785964479 @default.
- W3034377897 cites W2789447956 @default.
- W3034377897 cites W2789769337 @default.
- W3034377897 cites W2790560460 @default.
- W3034377897 cites W2794155473 @default.
- W3034377897 cites W2795241760 @default.
- W3034377897 cites W2795824476 @default.
- W3034377897 cites W2798107870 @default.
- W3034377897 cites W2800481810 @default.
- W3034377897 cites W2800706176 @default.
- W3034377897 cites W2801814443 @default.
- W3034377897 cites W2802597629 @default.
- W3034377897 cites W2803416433 @default.
- W3034377897 cites W2803483268 @default.
- W3034377897 cites W2805661401 @default.
- W3034377897 cites W2805961026 @default.
- W3034377897 cites W2805967746 @default.
- W3034377897 cites W2807564673 @default.
- W3034377897 cites W2809307170 @default.
- W3034377897 cites W2809439583 @default.
- W3034377897 cites W2809529985 @default.
- W3034377897 cites W2810200958 @default.
- W3034377897 cites W2810308689 @default.
- W3034377897 cites W2810460999 @default.
- W3034377897 cites W2810492961 @default.
- W3034377897 cites W2810680026 @default.
- W3034377897 cites W2810949835 @default.
- W3034377897 cites W2811455672 @default.