Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034381808> ?p ?o ?g. }
- W3034381808 endingPage "13" @default.
- W3034381808 startingPage "1" @default.
- W3034381808 abstract "Galangin, a natural flavonoid product derived from the root of galangal, is emerging as a promising anticancer agent against multiple cancers. Yet, whether it also has antitumor effects on cholangiocarcinoma (CCA) and the underlying mechanism is still unknown. Herein, we demonstrate that galangin exhibits multiple antitumor effects on CCA cells including decreases cell viability; inhibits proliferation, migration, and invasion; and induces apoptosis. Moreover, those phenotypic changes are associated with downregulated microRNA-21 (miR-21) expression. To support, overexpression of miR-21 blocks galangin-mediated antisurvival and metastasis effects on CCA cells. Mechanically, galangin increases the expression of phosphatase and tensin homolog (PTEN), a direct target of miR-21, resulting in decreased phosphorylation of AKT, a protein kinase which plays a critical role in controlling survival and apoptosis. In contrast, overexpression of miR-21 abrogates galangin-regulated PTEN expression and AKT phosphorylation. Taken together, these findings indicate that galangin inhibits CCA cell proliferation and metastasis and induces cell apoptosis through a miR-21-dependent manner, and galangin may provide a novel potential therapeutic adjuvant to treat CCA." @default.
- W3034381808 created "2020-06-19" @default.
- W3034381808 creator A5003460722 @default.
- W3034381808 creator A5009436247 @default.
- W3034381808 creator A5017296972 @default.
- W3034381808 creator A5020307714 @default.
- W3034381808 creator A5035194479 @default.
- W3034381808 creator A5037193653 @default.
- W3034381808 creator A5043682710 @default.
- W3034381808 creator A5047313425 @default.
- W3034381808 creator A5070046055 @default.
- W3034381808 creator A5072970489 @default.
- W3034381808 creator A5081182059 @default.
- W3034381808 creator A5084252227 @default.
- W3034381808 date "2020-06-12" @default.
- W3034381808 modified "2023-10-16" @default.
- W3034381808 title "Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression" @default.
- W3034381808 cites W1547685265 @default.
- W3034381808 cites W1547736903 @default.
- W3034381808 cites W1980998456 @default.
- W3034381808 cites W1990645475 @default.
- W3034381808 cites W1999437680 @default.
- W3034381808 cites W2001620773 @default.
- W3034381808 cites W2002097423 @default.
- W3034381808 cites W2002995168 @default.
- W3034381808 cites W2003753299 @default.
- W3034381808 cites W2004346157 @default.
- W3034381808 cites W2021568852 @default.
- W3034381808 cites W2024611216 @default.
- W3034381808 cites W2025590891 @default.
- W3034381808 cites W2032626834 @default.
- W3034381808 cites W2035515971 @default.
- W3034381808 cites W2038939944 @default.
- W3034381808 cites W2040776936 @default.
- W3034381808 cites W2067605157 @default.
- W3034381808 cites W2071776374 @default.
- W3034381808 cites W2106140153 @default.
- W3034381808 cites W2115261608 @default.
- W3034381808 cites W2117933729 @default.
- W3034381808 cites W2133540186 @default.
- W3034381808 cites W2139793739 @default.
- W3034381808 cites W2146621833 @default.
- W3034381808 cites W2154711900 @default.
- W3034381808 cites W2161163389 @default.
- W3034381808 cites W2309818502 @default.
- W3034381808 cites W2312787520 @default.
- W3034381808 cites W2525062594 @default.
- W3034381808 cites W2555801679 @default.
- W3034381808 cites W2620500305 @default.
- W3034381808 cites W2731446189 @default.
- W3034381808 cites W2767523520 @default.
- W3034381808 cites W2782134822 @default.
- W3034381808 cites W2805272029 @default.
- W3034381808 cites W4211025847 @default.
- W3034381808 doi "https://doi.org/10.1155/2020/5846938" @default.
- W3034381808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7306077" @default.
- W3034381808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32626749" @default.
- W3034381808 hasPublicationYear "2020" @default.
- W3034381808 type Work @default.
- W3034381808 sameAs 3034381808 @default.
- W3034381808 citedByCount "13" @default.
- W3034381808 countsByYear W30343818082020 @default.
- W3034381808 countsByYear W30343818082021 @default.
- W3034381808 countsByYear W30343818082022 @default.
- W3034381808 countsByYear W30343818082023 @default.
- W3034381808 crossrefType "journal-article" @default.
- W3034381808 hasAuthorship W3034381808A5003460722 @default.
- W3034381808 hasAuthorship W3034381808A5009436247 @default.
- W3034381808 hasAuthorship W3034381808A5017296972 @default.
- W3034381808 hasAuthorship W3034381808A5020307714 @default.
- W3034381808 hasAuthorship W3034381808A5035194479 @default.
- W3034381808 hasAuthorship W3034381808A5037193653 @default.
- W3034381808 hasAuthorship W3034381808A5043682710 @default.
- W3034381808 hasAuthorship W3034381808A5047313425 @default.
- W3034381808 hasAuthorship W3034381808A5070046055 @default.
- W3034381808 hasAuthorship W3034381808A5072970489 @default.
- W3034381808 hasAuthorship W3034381808A5081182059 @default.
- W3034381808 hasAuthorship W3034381808A5084252227 @default.
- W3034381808 hasBestOaLocation W30343818081 @default.
- W3034381808 hasConcept C104317684 @default.
- W3034381808 hasConcept C11960822 @default.
- W3034381808 hasConcept C121608353 @default.
- W3034381808 hasConcept C127561419 @default.
- W3034381808 hasConcept C145059251 @default.
- W3034381808 hasConcept C185592680 @default.
- W3034381808 hasConcept C190283241 @default.
- W3034381808 hasConcept C2777302768 @default.
- W3034381808 hasConcept C2777609662 @default.
- W3034381808 hasConcept C2777810353 @default.
- W3034381808 hasConcept C2778004101 @default.
- W3034381808 hasConcept C2779013556 @default.
- W3034381808 hasConcept C2779054382 @default.
- W3034381808 hasConcept C2779549131 @default.
- W3034381808 hasConcept C502942594 @default.
- W3034381808 hasConcept C54355233 @default.
- W3034381808 hasConcept C55493867 @default.
- W3034381808 hasConcept C62112901 @default.
- W3034381808 hasConcept C62478195 @default.