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- W3034382140 endingPage "760" @default.
- W3034382140 startingPage "739" @default.
- W3034382140 abstract "Introduction The clinical development of antiretroviral drugs has been followed by a rapid and concomitant development of HIV drug resistance. The development and spread of HIV drug resistance is due on the one hand to the within-host intrinsic HIV evolutionary rate and on the other to the wide use of low genetic barrier antiretrovirals.Areas covered We searched PubMed and Embase on 31 January 2020, for studies reporting antiretroviral resistance and pharmacology. In this review, we assessed the molecular target and mechanism of drug resistance development of the different antiretroviral classes focusing on the currently approved antiretroviral drugs. Then, we assessed the main pharmacokinetic/pharmacodynamic of the antiretrovirals. Finally, we retraced the history of antiretroviral treatment and its interconnection with antiretroviral worldwide resistance development both in , and middle-income countries in the perspective of 90–90-90 World Health Organization target.Expert opinion Drug resistance development is an invariably evolutionary driven phenomenon, which challenge the 90–90-90 target. In high-income countries, the antiretroviral drug resistance seems to be stable since the last decade. On the contrary, multi-intervention strategies comprehensive of broad availability of high genetic barrier regimens should be implemented in resource-limited setting to curb the rise of drug resistance." @default.
- W3034382140 created "2020-06-19" @default.
- W3034382140 creator A5016846891 @default.
- W3034382140 creator A5044171804 @default.
- W3034382140 creator A5074089696 @default.
- W3034382140 date "2020-06-30" @default.
- W3034382140 modified "2023-10-18" @default.
- W3034382140 title "The crosstalk between antiretrovirals pharmacology and HIV drug resistance" @default.
- W3034382140 cites W124544113 @default.
- W3034382140 cites W1501551071 @default.
- W3034382140 cites W1513200243 @default.
- W3034382140 cites W16565033 @default.
- W3034382140 cites W1866224665 @default.
- W3034382140 cites W1895373002 @default.
- W3034382140 cites W1898849923 @default.
- W3034382140 cites W1913784346 @default.
- W3034382140 cites W1940770670 @default.
- W3034382140 cites W1965104792 @default.
- W3034382140 cites W1966808583 @default.
- W3034382140 cites W1967390610 @default.
- W3034382140 cites W1973711348 @default.
- W3034382140 cites W1981458531 @default.
- W3034382140 cites W1981712752 @default.
- W3034382140 cites W1982235503 @default.
- W3034382140 cites W1983252661 @default.
- W3034382140 cites W1990069515 @default.
- W3034382140 cites W1990925084 @default.
- W3034382140 cites W1991918313 @default.
- W3034382140 cites W1993412676 @default.
- W3034382140 cites W1993857191 @default.
- W3034382140 cites W1996021566 @default.
- W3034382140 cites W1996564823 @default.
- W3034382140 cites W1997931264 @default.
- W3034382140 cites W1998085351 @default.
- W3034382140 cites W1998698366 @default.
- W3034382140 cites W1999365461 @default.
- W3034382140 cites W1999580368 @default.
- W3034382140 cites W2002104731 @default.
- W3034382140 cites W2003238700 @default.
- W3034382140 cites W2004631160 @default.
- W3034382140 cites W2007501521 @default.
- W3034382140 cites W2009155779 @default.
- W3034382140 cites W2009515164 @default.
- W3034382140 cites W2009581957 @default.
- W3034382140 cites W2012639630 @default.
- W3034382140 cites W2014890179 @default.
- W3034382140 cites W2015171620 @default.
- W3034382140 cites W2018973665 @default.
- W3034382140 cites W2021118597 @default.
- W3034382140 cites W2023257490 @default.
- W3034382140 cites W2024823439 @default.
- W3034382140 cites W2025152688 @default.
- W3034382140 cites W2025444624 @default.
- W3034382140 cites W2026250203 @default.
- W3034382140 cites W2030292215 @default.
- W3034382140 cites W2031845569 @default.
- W3034382140 cites W2032223070 @default.
- W3034382140 cites W2032959558 @default.
- W3034382140 cites W2034470753 @default.
- W3034382140 cites W2034741032 @default.
- W3034382140 cites W2036597966 @default.
- W3034382140 cites W2037635462 @default.
- W3034382140 cites W2038729300 @default.
- W3034382140 cites W2042830298 @default.
- W3034382140 cites W2043477103 @default.
- W3034382140 cites W2044864734 @default.
- W3034382140 cites W2045241078 @default.
- W3034382140 cites W2046418657 @default.
- W3034382140 cites W2048114154 @default.
- W3034382140 cites W2051116409 @default.
- W3034382140 cites W2052853915 @default.
- W3034382140 cites W2053125329 @default.
- W3034382140 cites W2057925552 @default.
- W3034382140 cites W2058144505 @default.
- W3034382140 cites W2060870465 @default.
- W3034382140 cites W2061212708 @default.
- W3034382140 cites W2063600611 @default.
- W3034382140 cites W2064570326 @default.
- W3034382140 cites W2065040389 @default.
- W3034382140 cites W2065740427 @default.
- W3034382140 cites W2068095506 @default.
- W3034382140 cites W2069078286 @default.
- W3034382140 cites W2069388608 @default.
- W3034382140 cites W2071440341 @default.
- W3034382140 cites W2072041078 @default.
- W3034382140 cites W2074411784 @default.
- W3034382140 cites W2075144974 @default.
- W3034382140 cites W2076228264 @default.
- W3034382140 cites W2076339980 @default.
- W3034382140 cites W2077473920 @default.
- W3034382140 cites W2077754502 @default.
- W3034382140 cites W2077814586 @default.
- W3034382140 cites W2081024741 @default.
- W3034382140 cites W2081686997 @default.
- W3034382140 cites W2084131702 @default.
- W3034382140 cites W2085088518 @default.
- W3034382140 cites W2086186867 @default.
- W3034382140 cites W2086462809 @default.