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- W3034382925 endingPage "103482" @default.
- W3034382925 startingPage "103482" @default.
- W3034382925 abstract "The role of the different components of the respiratory network in the mediation of opioid-induced respiratory depression is still unclear. We investigated the contribution of the preBötzinger Complex (preBötC) and the neighbouring Bötzinger Complex (BötC) and inspiratory portion of the ventral respiratory group (iVRG) in anesthetized, vagotomized, paralyzed and artificially ventilated adult rabbits making use of bilateral microinjections (30−50 nl) of the μ-opioid receptor agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO). Dose-dependent effects were observed. In the preBötC and the BötC 0.1 mM DAMGO microinjections caused mainly reductions in peak phrenic amplitude associated with tonic phrenic activity and irregular (ataxic) patterns of breathing that were more pronounced in the preBötC. Apneic effects developed at 0.5 mM. In the iVRG DAMGO provoked decreases in amplitude and frequency of phrenic bursts at 0.1 mM and apnea at 0.5 mM. Local 5 mM naloxone reversed the apneic effects. The results imply that different components of the respiratory network may contribute to opioid-induced respiratory disorders." @default.
- W3034382925 created "2020-06-19" @default.
- W3034382925 creator A5030377864 @default.
- W3034382925 creator A5032136373 @default.
- W3034382925 creator A5066359717 @default.
- W3034382925 creator A5075780586 @default.
- W3034382925 date "2020-09-01" @default.
- W3034382925 modified "2023-10-14" @default.
- W3034382925 title "Activation of μ-opioid receptors differentially affects the preBötzinger Complex and neighbouring regions of the respiratory network in the adult rabbit" @default.
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- W3034382925 doi "https://doi.org/10.1016/j.resp.2020.103482" @default.
- W3034382925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32553889" @default.
- W3034382925 hasPublicationYear "2020" @default.
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