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• W3034397401 abstract "Introduction Circulating tumor cells (CTC) and more recently, CTC clusters are implicated as a fundamental mechanism by which tumor cells break away from the primary site and travel to distant sites. Enumeration of CTC and CTC clusters represents a new approach to prognosis, prediction, and response to therapy in patients with early and metastatic breast cancer. Several recent studies have shown the predictive importance of monitoring CTCs levels in progression-free and overall survival in breast cancer patients. This review will focus on CTC enumeration and characterization in breast cancers.Areas covered We will provide a historical perspective and clinical background of CTC detection in peripheral blood. The current methodologies for studying CTCs and newer technologies for CTC detection will be reviewed together with the current state of the art of CTCs as a biomarker in risk stratification and prognostication in breast cancers.Expert opinion Currently, there is an FDA approved CTC assessment method for clinical use. While CTC enumeration, is a marker for prognostication and survival, molecular characterization of CTC, may be more accurate in monitoring response to treatment due to tumor heterogeneity rather than the tumor phenotype at the primary or metastatic sites." @default.
• W3034397401 created "2020-06-19" @default.
• W3034397401 creator A5015766551 @default.
• W3034397401 creator A5041179069 @default.
• W3034397401 creator A5061937236 @default.
• W3034397401 date "2020-06-30" @default.
• W3034397401 modified "2023-09-26" @default.
• W3034397401 title "Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer" @default.
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• W3034397401 doi "https://doi.org/10.1080/14737159.2020.1784009" @default.
• W3034397401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32546017" @default.
• W3034397401 hasPublicationYear "2020" @default.
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