FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034408306> ?p ?o ?g. }

• W3034408306 endingPage "786" @default.
• W3034408306 startingPage "785" @default.
• W3034408306 abstract "Background: There are few data about variations in bone metabolism associated with weight loss in obese patients undergoing bariatric surgery. Objectives: To assess the influence on the bone metabolism of bariatric surgery in morbidly obese patients. Methods: Longitudinal pre-post study with analytical components. All morbidly obese patients undergoing bariatric surgery were, prior to this, referred to Rheumatology Department. In all cases, the baseline characteristics of the patients were collected and a complete bone metabolic analytical study and bone densitometry (BMD) were requested. This same study was repeated one year later, with a window period of ± 3 months. Statistical analysis was performed with the SPSS 20.0 software. Results: Of the 91 patients included in the study and who underwent baseline BMD and analytical tests prior to surgery, only follow-up data of 27 patients could be collected at the time of the present data analysis. Within this sample, the median age was 54 years (AIQ 11), with 6 men and 21 women (11 premenopausal, 10 postmenopausal). Prior to surgery, median body mass index (BMI) was 39.2 (AIQ4.43) and median vitamin D (25OHD) level was 22 (AIQ 16). High values of PTH were detected in two patients. Regarding baseline BMD, 78% had normal values and 22% had values in the range of osteopenia. After surgery, all patients presented a significant weight loss, being the median loss in BMI per year 9.8 Kg/m 2 (AIQ 3.8) as absolute value, and 25% (AIQ 8.12) as a percentage value. This weight loss was accompanied by a significant BMD worsening that was evident in all locations: lumbar spine (median -6.97%, AIQ 6.3), total hip (median -6.4%, AIQ 7.7) and femoral neck (median -3.57 %, AIQ 8); so that an additional 22% of patients changed to osteopenia values. All this despite a significant increase in 25OHD levels in all cases (35.7%; AIQ 52.3). No clinical or morphometric fractures were collected. Despite the parallel evolutionary course, the loss of BMI only showed a tendency to correlate with the decrease in bone mass in the femoral neck (p-value 0.089), but not in the other locations. Conclusion: In our sample of morbidly obese patients undergoing bariatric surgery, there is a significant and widespread loss of bone mineral density one year after the procedure, all this despite the supplementation and the increase in 25OHD levels. This loss only seems to be directly related to the decrease in weight at the femoral neck, just probably by a mechanism to reduce mechanical load. Disclosure of Interests: I Vázquez-Gómez: None declared, Ramón Trullenque Juan: None declared, Carlos Morillas Ariño: None declared, L Montolio-Chiva: None declared, Ana V Orenes Vera: None declared, Eduardo Flores: None declared, Elia Valls-Pascual Grant/research support from: Roche, Novartis, and AbbVie, Speakers bureau: AbbVie, Lilly, Pfizer, MSD, Novartis, Janssen, Bristol Myers Squibb, UCB Pharma, Desamparados Ybañez: None declared, À Martínez-Ferrer: None declared, Inmaculada Torner Hernández: None declared, V Núñez-Monje: None declared, A Sendra-García: None declared, Juanjo J Alegre-Sancho Consultant of: UCB, Roche, Sanofi, Boehringer, Celltrion, Paid instructor for: GSK, Speakers bureau: MSD, GSK, Lilly, Sanofi, Roche, UCB, Actelion, Pfizer, Abbvie, Novartis" @default.
• W3034408306 created "2020-06-19" @default.
• W3034408306 creator A5007767181 @default.
• W3034408306 creator A5017737410 @default.
• W3034408306 creator A5023873922 @default.
• W3034408306 creator A5025639317 @default.
• W3034408306 creator A5032830139 @default.
• W3034408306 creator A5047743222 @default.
• W3034408306 creator A5060655093 @default.
• W3034408306 creator A5067244908 @default.
• W3034408306 creator A5068570845 @default.
• W3034408306 creator A5069395382 @default.
• W3034408306 creator A5075137617 @default.
• W3034408306 creator A5081850361 @default.
• W3034408306 creator A5085603201 @default.
• W3034408306 date "2020-06-01" @default.
• W3034408306 modified "2023-10-12" @default.
• W3034408306 title "FRI0377 BARIATRIC SURGERY: EFFECTS ON BONE METABOLISM" @default.
• W3034408306 doi "https://doi.org/10.1136/annrheumdis-2020-eular.6258" @default.
• W3034408306 hasPublicationYear "2020" @default.
• W3034408306 type Work @default.
• W3034408306 sameAs 3034408306 @default.
• W3034408306 citedByCount "0" @default.
• W3034408306 crossrefType "journal-article" @default.
• W3034408306 hasAuthorship W3034408306A5007767181 @default.
• W3034408306 hasAuthorship W3034408306A5017737410 @default.
• W3034408306 hasAuthorship W3034408306A5023873922 @default.
• W3034408306 hasAuthorship W3034408306A5025639317 @default.
• W3034408306 hasAuthorship W3034408306A5032830139 @default.
• W3034408306 hasAuthorship W3034408306A5047743222 @default.
• W3034408306 hasAuthorship W3034408306A5060655093 @default.
• W3034408306 hasAuthorship W3034408306A5067244908 @default.
• W3034408306 hasAuthorship W3034408306A5068570845 @default.
• W3034408306 hasAuthorship W3034408306A5069395382 @default.
• W3034408306 hasAuthorship W3034408306A5075137617 @default.
• W3034408306 hasAuthorship W3034408306A5081850361 @default.
• W3034408306 hasAuthorship W3034408306A5085603201 @default.
• W3034408306 hasConcept C126322002 @default.
• W3034408306 hasConcept C141071460 @default.
• W3034408306 hasConcept C170033053 @default.
• W3034408306 hasConcept C2776541429 @default.
• W3034408306 hasConcept C2776886416 @default.
• W3034408306 hasConcept C2777083390 @default.
• W3034408306 hasConcept C2779329777 @default.
• W3034408306 hasConcept C2780221984 @default.
• W3034408306 hasConcept C3019948525 @default.
• W3034408306 hasConcept C511355011 @default.
• W3034408306 hasConcept C544821477 @default.
• W3034408306 hasConcept C68312169 @default.
• W3034408306 hasConcept C71924100 @default.
• W3034408306 hasConceptScore W3034408306C126322002 @default.
• W3034408306 hasConceptScore W3034408306C141071460 @default.
• W3034408306 hasConceptScore W3034408306C170033053 @default.
• W3034408306 hasConceptScore W3034408306C2776541429 @default.
• W3034408306 hasConceptScore W3034408306C2776886416 @default.
• W3034408306 hasConceptScore W3034408306C2777083390 @default.
• W3034408306 hasConceptScore W3034408306C2779329777 @default.
• W3034408306 hasConceptScore W3034408306C2780221984 @default.
• W3034408306 hasConceptScore W3034408306C3019948525 @default.
• W3034408306 hasConceptScore W3034408306C511355011 @default.
• W3034408306 hasConceptScore W3034408306C544821477 @default.
• W3034408306 hasConceptScore W3034408306C68312169 @default.
• W3034408306 hasConceptScore W3034408306C71924100 @default.
• W3034408306 hasIssue "Suppl 1" @default.
• W3034408306 hasLocation W30344083061 @default.
• W3034408306 hasOpenAccess W3034408306 @default.
• W3034408306 hasPrimaryLocation W30344083061 @default.
• W3034408306 hasRelatedWork W1786411514 @default.
• W3034408306 hasRelatedWork W2004751374 @default.
• W3034408306 hasRelatedWork W2110400973 @default.
• W3034408306 hasRelatedWork W2416740207 @default.
• W3034408306 hasRelatedWork W2473844262 @default.
• W3034408306 hasRelatedWork W2498556610 @default.
• W3034408306 hasRelatedWork W2598355301 @default.
• W3034408306 hasRelatedWork W3030667799 @default.
• W3034408306 hasRelatedWork W3170002878 @default.
• W3034408306 hasRelatedWork W2081521625 @default.
• W3034408306 hasVolume "79" @default.
• W3034408306 isParatext "false" @default.
• W3034408306 isRetracted "false" @default.
• W3034408306 magId "3034408306" @default.
• W3034408306 workType "article" @default.