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- W3034417639 abstract "Abstract Tumors with an impaired transporter associated with antigen processing (TAP) present several ER-derived self-antigens on HLA class I (HLA-I) which are absent on healthy cells. Selection of such TAP-independent antigens for T cell-based immunotherapy should include analysis of their expression on healthy cells to prevent therapy-induced adverse toxicities. However, it is unknown how the absence of clinically relevant antigens on healthy cells needs to be validated. Here we monitored TAP-independent antigen presentation on various healthy cells using a new toolbox consisting of a T cell clone recognizing a TAP-independent SSR1-derived antigen. We found that most but not all healthy cells present this antigen under normal and inflammatory conditions, indicating that TAP-independent antigen presentation is a variable phenomenon. Our data emphasize the necessity of extensive testing of a wide variety of healthy cell types to define clinically relevant TAP-independent antigens that can be safely targeted by immunotherapy." @default.
- W3034417639 created "2020-06-19" @default.
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- W3034417639 date "2020-06-12" @default.
- W3034417639 modified "2023-09-23" @default.
- W3034417639 title "Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens" @default.
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- W3034417639 doi "https://doi.org/10.1101/2020.06.11.146449" @default.
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