FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034500973> ?p ?o ?g. }

• W3034500973 endingPage "175" @default.
• W3034500973 startingPage "151" @default.
• W3034500973 abstract "Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO) constantly leads to lipid accretion in liver. However, much less is known about the mechanism(s) of drug-induced steatosis in the absence of severe mitochondrial dysfunction, although previous studies suggested the involvement of mild-to-moderate inhibition of mtFAO, increased de novo lipogenesis (DNL), and impairment of very low-density lipoprotein (VLDL) secretion. The objective of our study, mainly carried out in human hepatoma HepaRG cells, was to investigate these 3 mechanisms with 12 drugs able to induce steatosis in human: amiodarone (AMIO, used as positive control), allopurinol (ALLO), D-penicillamine (DPEN), 5-fluorouracil (5FU), indinavir (INDI), indomethacin (INDO), methimazole (METHI), methotrexate (METHO), nifedipine (NIF), rifampicin (RIF), sulindac (SUL), and troglitazone (TRO). Hepatic cells were exposed to drugs for 4 days with concentrations decreasing ATP level by less than 30% as compared to control and not exceeding 100 × Cmax. Among the 12 drugs, AMIO, ALLO, 5FU, INDI, INDO, METHO, RIF, SUL, and TRO induced steatosis in HepaRG cells. AMIO, INDO, and RIF decreased mtFAO. AMIO, INDO, and SUL enhanced DNL. ALLO, 5FU, INDI, INDO, SUL, RIF, and TRO impaired VLDL secretion. These seven drugs reduced the mRNA level of genes playing a major role in VLDL assembly and also induced endoplasmic reticulum (ER) stress. Thus, in the absence of severe mitochondrial dysfunction, drug-induced steatosis can be triggered by different mechanisms, although impairment of VLDL secretion seems more frequently involved, possibly as a consequence of ER stress." @default.
• W3034500973 created "2020-06-19" @default.
• W3034500973 creator A5008801222 @default.
• W3034500973 creator A5014451095 @default.
• W3034500973 creator A5017971250 @default.
• W3034500973 creator A5021292416 @default.
• W3034500973 creator A5027481816 @default.
• W3034500973 creator A5033729639 @default.
• W3034500973 creator A5056016094 @default.
• W3034500973 creator A5059088776 @default.
• W3034500973 creator A5063215068 @default.
• W3034500973 creator A5071474044 @default.
• W3034500973 creator A5089916612 @default.
• W3034500973 creator A5089942508 @default.
• W3034500973 date "2020-06-14" @default.
• W3034500973 modified "2023-10-18" @default.
• W3034500973 title "Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity" @default.
• W3034500973 cites W1822042631 @default.
• W3034500973 cites W1911086420 @default.
• W3034500973 cites W1964624702 @default.
• W3034500973 cites W1966201512 @default.
• W3034500973 cites W1966625828 @default.
• W3034500973 cites W1967993903 @default.
• W3034500973 cites W1972156785 @default.
• W3034500973 cites W1974734412 @default.
• W3034500973 cites W1976671221 @default.
• W3034500973 cites W1984171106 @default.
• W3034500973 cites W1997121318 @default.
• W3034500973 cites W1998370769 @default.
• W3034500973 cites W2000755812 @default.
• W3034500973 cites W2001689124 @default.
• W3034500973 cites W2003755766 @default.
• W3034500973 cites W2009841005 @default.
• W3034500973 cites W2010965956 @default.
• W3034500973 cites W2015942708 @default.
• W3034500973 cites W2016716965 @default.
• W3034500973 cites W2022837209 @default.
• W3034500973 cites W2023453711 @default.
• W3034500973 cites W2027143635 @default.
• W3034500973 cites W2037187444 @default.
• W3034500973 cites W2037667733 @default.
• W3034500973 cites W2039154639 @default.
• W3034500973 cites W2041953515 @default.
• W3034500973 cites W2052356187 @default.
• W3034500973 cites W2061945989 @default.
• W3034500973 cites W2070196278 @default.
• W3034500973 cites W2075528397 @default.
• W3034500973 cites W2077386971 @default.
• W3034500973 cites W2077728043 @default.
• W3034500973 cites W2078197243 @default.
• W3034500973 cites W2084658764 @default.
• W3034500973 cites W2089108588 @default.
• W3034500973 cites W2095968062 @default.
• W3034500973 cites W2103750442 @default.
• W3034500973 cites W2116665045 @default.
• W3034500973 cites W2116993390 @default.
• W3034500973 cites W2121699889 @default.
• W3034500973 cites W2127012454 @default.
• W3034500973 cites W2128852331 @default.
• W3034500973 cites W2132272495 @default.
• W3034500973 cites W2133620886 @default.
• W3034500973 cites W2134579258 @default.
• W3034500973 cites W2137595711 @default.
• W3034500973 cites W2143511244 @default.
• W3034500973 cites W2148488063 @default.
• W3034500973 cites W2154754322 @default.
• W3034500973 cites W2158686289 @default.
• W3034500973 cites W2165200875 @default.
• W3034500973 cites W2296788119 @default.
• W3034500973 cites W2321993463 @default.
• W3034500973 cites W2340588852 @default.
• W3034500973 cites W2405416662 @default.
• W3034500973 cites W2513893629 @default.
• W3034500973 cites W2516169663 @default.
• W3034500973 cites W2563038139 @default.
• W3034500973 cites W2594518615 @default.
• W3034500973 cites W2743837016 @default.
• W3034500973 cites W2787886563 @default.
• W3034500973 cites W2789815476 @default.
• W3034500973 cites W2792817083 @default.
• W3034500973 cites W2799964529 @default.
• W3034500973 cites W2883576091 @default.
• W3034500973 cites W2905646788 @default.
• W3034500973 cites W2911306037 @default.
• W3034500973 cites W2917942507 @default.
• W3034500973 cites W2951672084 @default.
• W3034500973 cites W2979888676 @default.
• W3034500973 cites W4210980460 @default.
• W3034500973 doi "https://doi.org/10.1007/s10565-020-09537-1" @default.
• W3034500973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8012331" @default.
• W3034500973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32535746" @default.
• W3034500973 hasPublicationYear "2020" @default.
• W3034500973 type Work @default.
• W3034500973 sameAs 3034500973 @default.
• W3034500973 citedByCount "20" @default.
• W3034500973 countsByYear W30345009732021 @default.
• W3034500973 countsByYear W30345009732022 @default.
• W3034500973 countsByYear W30345009732023 @default.

• next