Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034502519> ?p ?o ?g. }
- W3034502519 endingPage "1139" @default.
- W3034502519 startingPage "1127" @default.
- W3034502519 abstract "DNA is a highly polyanionic biomolecule that complexes with both collagen and hydroxyapatite. By combining these complexes, we synthesized nucleic-acid collagen complexes (NACC) mineralized with hydroxyapatite. The composite complexes were made using a short, monodisperse single-stranded DNA, type I collagen, and mineralizing medium. They rapidly self-assembled into both mineralized NACC microfibers and 3D NACC gels. At the nanoscale, these complexes are hierarchical, interwoven, curly nanofibrils resembling native extracellular matrix, which mineralized an interpenetrating nanocrystalline hydroxyapatite phase. Mineralization was able to be done either before or after NACC formation enabling temporal control of the process. In response to the NACC material, primary human osteoblasts took on an osteocyte-like morphology. Moreover, the cells agglomerated and remodeled the NACC gels into densified, tissue-like structures within 3 days. NACC fibers and gels have promise not only as osteoconductive coatings and scaffolds, but as coatings and scaffolds for any tissue using this new form of naturally-derived biomaterials." @default.
- W3034502519 created "2020-06-19" @default.
- W3034502519 creator A5036162806 @default.
- W3034502519 creator A5043795016 @default.
- W3034502519 creator A5045894918 @default.
- W3034502519 creator A5063000820 @default.
- W3034502519 date "2020-10-01" @default.
- W3034502519 modified "2023-09-26" @default.
- W3034502519 title "Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering" @default.
- W3034502519 cites W1187973597 @default.
- W3034502519 cites W1549511377 @default.
- W3034502519 cites W1602919907 @default.
- W3034502519 cites W1963492196 @default.
- W3034502519 cites W1965372133 @default.
- W3034502519 cites W1971835799 @default.
- W3034502519 cites W1975666052 @default.
- W3034502519 cites W1979728286 @default.
- W3034502519 cites W1980286576 @default.
- W3034502519 cites W1980751943 @default.
- W3034502519 cites W1983160258 @default.
- W3034502519 cites W1986903179 @default.
- W3034502519 cites W1987944808 @default.
- W3034502519 cites W1990425164 @default.
- W3034502519 cites W1990880240 @default.
- W3034502519 cites W1993053684 @default.
- W3034502519 cites W2002398258 @default.
- W3034502519 cites W2006799813 @default.
- W3034502519 cites W2007310752 @default.
- W3034502519 cites W2018957920 @default.
- W3034502519 cites W2019582558 @default.
- W3034502519 cites W2023026872 @default.
- W3034502519 cites W2031368008 @default.
- W3034502519 cites W2035982352 @default.
- W3034502519 cites W2039473669 @default.
- W3034502519 cites W2043032069 @default.
- W3034502519 cites W2046239064 @default.
- W3034502519 cites W2049172960 @default.
- W3034502519 cites W2053557358 @default.
- W3034502519 cites W2053836650 @default.
- W3034502519 cites W2061897160 @default.
- W3034502519 cites W2064161502 @default.
- W3034502519 cites W2066168053 @default.
- W3034502519 cites W2068511668 @default.
- W3034502519 cites W2071100665 @default.
- W3034502519 cites W2071823872 @default.
- W3034502519 cites W2078386735 @default.
- W3034502519 cites W2080593732 @default.
- W3034502519 cites W2080854747 @default.
- W3034502519 cites W2083906328 @default.
- W3034502519 cites W2085459553 @default.
- W3034502519 cites W2091309872 @default.
- W3034502519 cites W2092477212 @default.
- W3034502519 cites W2101214298 @default.
- W3034502519 cites W2111801168 @default.
- W3034502519 cites W2127000141 @default.
- W3034502519 cites W2133742529 @default.
- W3034502519 cites W2142302926 @default.
- W3034502519 cites W2179722802 @default.
- W3034502519 cites W2225056950 @default.
- W3034502519 cites W2319375857 @default.
- W3034502519 cites W2330316978 @default.
- W3034502519 cites W2419516542 @default.
- W3034502519 cites W2547782348 @default.
- W3034502519 cites W2554078940 @default.
- W3034502519 cites W2770660183 @default.
- W3034502519 cites W2778873525 @default.
- W3034502519 cites W2889560635 @default.
- W3034502519 cites W2897776209 @default.
- W3034502519 cites W2910351659 @default.
- W3034502519 cites W2915664441 @default.
- W3034502519 cites W2920439209 @default.
- W3034502519 cites W2921736838 @default.
- W3034502519 cites W2964255807 @default.
- W3034502519 cites W2966283005 @default.
- W3034502519 cites W2970871127 @default.
- W3034502519 cites W2990453173 @default.
- W3034502519 cites W2996110224 @default.
- W3034502519 cites W3023959340 @default.
- W3034502519 cites W3028867707 @default.
- W3034502519 cites W3100472128 @default.
- W3034502519 cites W4210961063 @default.
- W3034502519 cites W4234648703 @default.
- W3034502519 cites W4239858085 @default.
- W3034502519 cites W1971077890 @default.
- W3034502519 doi "https://doi.org/10.1016/j.ijbiomac.2020.06.126" @default.
- W3034502519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7494536" @default.
- W3034502519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32561285" @default.
- W3034502519 hasPublicationYear "2020" @default.
- W3034502519 type Work @default.
- W3034502519 sameAs 3034502519 @default.
- W3034502519 citedByCount "10" @default.
- W3034502519 countsByYear W30345025192021 @default.
- W3034502519 countsByYear W30345025192022 @default.
- W3034502519 countsByYear W30345025192023 @default.
- W3034502519 crossrefType "journal-article" @default.
- W3034502519 hasAuthorship W3034502519A5036162806 @default.
- W3034502519 hasAuthorship W3034502519A5043795016 @default.
- W3034502519 hasAuthorship W3034502519A5045894918 @default.