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- W3034502758 abstract "Abstract Non-invasive and label-free calorimetry could become a disruptive technique to study single cell metabolic heat production without altering the cell behavior, but it is currently limited by insufficient sensitivity. Here, we demonstrate microfluidic single-cell calorimetry with 0.2-nW sensitivity, representing more than ten-fold enhancement over previous record, which is enabled by (i) a low-noise thermometry platform with ultralow long-term (10-h) temperature noise (80 μK) and (ii) a microfluidic channel-in-vacuum design allowing cell flow and nutrient delivery while maintaining a low thermal conductance of 2.5 μW K −1 . Using Tetrahymena thermophila as an example, we demonstrate on-chip single-cell calorimetry measurement with metabolic heat rates ranging from 1 to 4 nW, which are found to correlate well with the cell size. Finally, we perform real-time monitoring of metabolic rate stimulation by introducing a mitochondrial uncoupling agent to the microchannel, enabling determination of the spare respiratory capacity of the cells." @default.
- W3034502758 created "2020-06-19" @default.
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- W3034502758 date "2020-06-12" @default.
- W3034502758 modified "2023-09-23" @default.
- W3034502758 title "Sub-nanowatt microfluidic single-cell calorimetry" @default.
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- W3034502758 doi "https://doi.org/10.1038/s41467-020-16697-5" @default.
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