FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034505595> ?p ?o ?g. }

• W3034505595 endingPage "934S" @default.
• W3034505595 startingPage "925S" @default.
• W3034505595 abstract "Osteoarthritis (OA) is an age-related biomechanical and low-grade inflammometabolic disease of the joints and one of the costliest and disabling forms of arthritis. Studies on matrix-degrading enzymes such as metalloproteases, which are implicated in the increased catabolism of extracellular matrix, are of paramount relevance. DKK3 is a member of DKK family and is best known for its role in cancer. Although there is some information about the participation of DKK3 in cartilage pathophysiology and on metalloproteases regulation, in particular, little is known about DKK3 signaling mechanisms. Thus, the aim of this study is to explore how DKK3 regulates matrix metalloproteinase-13 (MMP-13) expression.Gene, protein expression and protein phosphorylation in primary human chondrocytes and ATDC5 mouse cells were assessed by RT-qPCR and Western blot analysis. Further studies on DKK3 activity were performed by targeting DKK3 gene with a specific siRNA.DKK3 expression was found to be higher in OA human chondrocytes than healthy cells, being its expression decreased in interleukin-1α (IL-1α)-stimulated cells. DKK3 knockdown increased the induction of MMP-13 elicited by IL-1α in human and mouse chondrocytes and after the analysis of different signalling pathways, we observed that NF-κB pathway was involved in the regulation of MMP-13 expression by DKK3.Herein we have demonstrated, for the first time, that DKK3 gene silencing exacerbated NF-κB activation, resulting in an increased IL-1α-driven induction of MMP-13. Our results further confirm that DKK3 may play a protective role in OA by attenuating NF-κB activation and the subsequent production of metalloproteases." @default.
• W3034505595 created "2020-06-19" @default.
• W3034505595 creator A5011112502 @default.
• W3034505595 creator A5013076020 @default.
• W3034505595 creator A5014810154 @default.
• W3034505595 creator A5015960269 @default.
• W3034505595 creator A5016922988 @default.
• W3034505595 creator A5024322272 @default.
• W3034505595 creator A5027201511 @default.
• W3034505595 creator A5041596182 @default.
• W3034505595 creator A5059950077 @default.
• W3034505595 creator A5062554228 @default.
• W3034505595 date "2020-06-12" @default.
• W3034505595 modified "2023-10-17" @default.
• W3034505595 title "Dickkopf-3 (DKK3) Signaling in IL-1α-Challenged Chondrocytes: Involvement of the NF-κB Pathway" @default.
• W3034505595 cites W1493844743 @default.
• W3034505595 cites W1515931733 @default.
• W3034505595 cites W1569539243 @default.
• W3034505595 cites W1773041043 @default.
• W3034505595 cites W1797559164 @default.
• W3034505595 cites W1962157876 @default.
• W3034505595 cites W1965665343 @default.
• W3034505595 cites W1966180339 @default.
• W3034505595 cites W1967073403 @default.
• W3034505595 cites W1974153797 @default.
• W3034505595 cites W1985608961 @default.
• W3034505595 cites W1993990835 @default.
• W3034505595 cites W1999963870 @default.
• W3034505595 cites W2030151430 @default.
• W3034505595 cites W2042391568 @default.
• W3034505595 cites W2055065987 @default.
• W3034505595 cites W2055808176 @default.
• W3034505595 cites W2070978045 @default.
• W3034505595 cites W2072692609 @default.
• W3034505595 cites W2094053175 @default.
• W3034505595 cites W2101471525 @default.
• W3034505595 cites W2132612143 @default.
• W3034505595 cites W2164270530 @default.
• W3034505595 cites W2236063251 @default.
• W3034505595 cites W2978756769 @default.
• W3034505595 cites W4251564069 @default.
• W3034505595 doi "https://doi.org/10.1177/1947603520933328" @default.
• W3034505595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32532182" @default.
• W3034505595 hasPublicationYear "2020" @default.
• W3034505595 type Work @default.
• W3034505595 sameAs 3034505595 @default.
• W3034505595 citedByCount "7" @default.
• W3034505595 countsByYear W30345055952020 @default.
• W3034505595 countsByYear W30345055952022 @default.
• W3034505595 countsByYear W30345055952023 @default.
• W3034505595 crossrefType "journal-article" @default.
• W3034505595 hasAuthorship W3034505595A5011112502 @default.
• W3034505595 hasAuthorship W3034505595A5013076020 @default.
• W3034505595 hasAuthorship W3034505595A5014810154 @default.
• W3034505595 hasAuthorship W3034505595A5015960269 @default.
• W3034505595 hasAuthorship W3034505595A5016922988 @default.
• W3034505595 hasAuthorship W3034505595A5024322272 @default.
• W3034505595 hasAuthorship W3034505595A5027201511 @default.
• W3034505595 hasAuthorship W3034505595A5041596182 @default.
• W3034505595 hasAuthorship W3034505595A5059950077 @default.
• W3034505595 hasAuthorship W3034505595A5062554228 @default.
• W3034505595 hasBestOaLocation W30345055951 @default.
• W3034505595 hasConcept C104317684 @default.
• W3034505595 hasConcept C109523444 @default.
• W3034505595 hasConcept C119056186 @default.
• W3034505595 hasConcept C126322002 @default.
• W3034505595 hasConcept C150194340 @default.
• W3034505595 hasConcept C173396325 @default.
• W3034505595 hasConcept C189165786 @default.
• W3034505595 hasConcept C203014093 @default.
• W3034505595 hasConcept C2776415932 @default.
• W3034505595 hasConcept C2777730290 @default.
• W3034505595 hasConcept C2910007452 @default.
• W3034505595 hasConcept C502942594 @default.
• W3034505595 hasConcept C54355233 @default.
• W3034505595 hasConcept C62478195 @default.
• W3034505595 hasConcept C71924100 @default.
• W3034505595 hasConcept C86803240 @default.
• W3034505595 hasConcept C95444343 @default.
• W3034505595 hasConceptScore W3034505595C104317684 @default.
• W3034505595 hasConceptScore W3034505595C109523444 @default.
• W3034505595 hasConceptScore W3034505595C119056186 @default.
• W3034505595 hasConceptScore W3034505595C126322002 @default.
• W3034505595 hasConceptScore W3034505595C150194340 @default.
• W3034505595 hasConceptScore W3034505595C173396325 @default.
• W3034505595 hasConceptScore W3034505595C189165786 @default.
• W3034505595 hasConceptScore W3034505595C203014093 @default.
• W3034505595 hasConceptScore W3034505595C2776415932 @default.
• W3034505595 hasConceptScore W3034505595C2777730290 @default.
• W3034505595 hasConceptScore W3034505595C2910007452 @default.
• W3034505595 hasConceptScore W3034505595C502942594 @default.
• W3034505595 hasConceptScore W3034505595C54355233 @default.
• W3034505595 hasConceptScore W3034505595C62478195 @default.
• W3034505595 hasConceptScore W3034505595C71924100 @default.
• W3034505595 hasConceptScore W3034505595C86803240 @default.
• W3034505595 hasConceptScore W3034505595C95444343 @default.
• W3034505595 hasFunder F4320326480 @default.
• W3034505595 hasFunder F4320334679 @default.

• next