Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034506688> ?p ?o ?g. }
- W3034506688 endingPage "374" @default.
- W3034506688 startingPage "374" @default.
- W3034506688 abstract "Bombyx mori silk protein genes are strictly turned on and off in different developmental stages under the hormone periodically change. The broad complex (BrC) is a transcription factor mediating 20-hydroxyecdysone action, which plays important roles during metamorphosis. Here, we observed that two isoforms of BmBrC (BmBrC-Z2 and BmBrC-Z4) exhibited contrasting expression patterns with fibroin genes (FibH, FibL and P25) in the posterior silk gland (PSG), suggesting that BmBrC may negatively regulate fibroin genes. Transgenic lines were constructed to ectopically overexpress BmBrC-Z2 in the PSG. The silk protein genes in the transgenic line were decreased to almost half of that in the wild type. The silk yield was decreased significantly. In addition, the expression levels of regulatory factors (BmKr-h1 and BmDimm) response to juvenile hormone (JH) signal were inhibited significantly. Then exogenous JH in the BmBrC-Z2 overexpressed lines can inhibit the expression of BmBrC-Z2 and activate the expression of silk protein genes and restore the silk yield to the level of the wild type. These results indicated that BmBrC may inhibit fibroin genes by repressing the JH signal pathway, which would assist in deciphering the comprehensive regulation mechanism of silk protein genes." @default.
- W3034506688 created "2020-06-19" @default.
- W3034506688 creator A5003759585 @default.
- W3034506688 creator A5011329059 @default.
- W3034506688 creator A5016443208 @default.
- W3034506688 creator A5016622484 @default.
- W3034506688 creator A5020691118 @default.
- W3034506688 creator A5044358832 @default.
- W3034506688 date "2020-06-16" @default.
- W3034506688 modified "2023-10-11" @default.
- W3034506688 title "Transgenic Ectopic Overexpression of Broad Complex (BrC-Z2) in the Silk Gland Inhibits the Expression of Silk Fibroin Genes of Bombyx mori" @default.
- W3034506688 cites W1430895357 @default.
- W3034506688 cites W1506185475 @default.
- W3034506688 cites W1869094958 @default.
- W3034506688 cites W1967643631 @default.
- W3034506688 cites W1999906746 @default.
- W3034506688 cites W2009795870 @default.
- W3034506688 cites W2014861681 @default.
- W3034506688 cites W2015367523 @default.
- W3034506688 cites W2021431871 @default.
- W3034506688 cites W2023572211 @default.
- W3034506688 cites W2026630212 @default.
- W3034506688 cites W2027382550 @default.
- W3034506688 cites W2027968607 @default.
- W3034506688 cites W2054031788 @default.
- W3034506688 cites W2056944517 @default.
- W3034506688 cites W2058160827 @default.
- W3034506688 cites W2059454854 @default.
- W3034506688 cites W2060122350 @default.
- W3034506688 cites W2061867847 @default.
- W3034506688 cites W2069013215 @default.
- W3034506688 cites W2077259981 @default.
- W3034506688 cites W2084850666 @default.
- W3034506688 cites W2115986203 @default.
- W3034506688 cites W2116476141 @default.
- W3034506688 cites W2120240537 @default.
- W3034506688 cites W2121382190 @default.
- W3034506688 cites W2146079535 @default.
- W3034506688 cites W2156108633 @default.
- W3034506688 cites W2158731648 @default.
- W3034506688 cites W2179812999 @default.
- W3034506688 cites W2215179541 @default.
- W3034506688 cites W2469874729 @default.
- W3034506688 cites W2488311265 @default.
- W3034506688 cites W2509051476 @default.
- W3034506688 cites W2565116506 @default.
- W3034506688 cites W2575634736 @default.
- W3034506688 cites W2604655553 @default.
- W3034506688 cites W2605351129 @default.
- W3034506688 cites W2624830532 @default.
- W3034506688 cites W2763738239 @default.
- W3034506688 cites W2903872288 @default.
- W3034506688 cites W2911636766 @default.
- W3034506688 cites W2912930145 @default.
- W3034506688 cites W2968932145 @default.
- W3034506688 doi "https://doi.org/10.3390/insects11060374" @default.
- W3034506688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7349191" @default.
- W3034506688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32560131" @default.
- W3034506688 hasPublicationYear "2020" @default.
- W3034506688 type Work @default.
- W3034506688 sameAs 3034506688 @default.
- W3034506688 citedByCount "5" @default.
- W3034506688 countsByYear W30345066882022 @default.
- W3034506688 countsByYear W30345066882023 @default.
- W3034506688 crossrefType "journal-article" @default.
- W3034506688 hasAuthorship W3034506688A5003759585 @default.
- W3034506688 hasAuthorship W3034506688A5011329059 @default.
- W3034506688 hasAuthorship W3034506688A5016443208 @default.
- W3034506688 hasAuthorship W3034506688A5016622484 @default.
- W3034506688 hasAuthorship W3034506688A5020691118 @default.
- W3034506688 hasAuthorship W3034506688A5044358832 @default.
- W3034506688 hasBestOaLocation W30345066881 @default.
- W3034506688 hasConcept C102230213 @default.
- W3034506688 hasConcept C104317684 @default.
- W3034506688 hasConcept C111919701 @default.
- W3034506688 hasConcept C122302759 @default.
- W3034506688 hasConcept C150194340 @default.
- W3034506688 hasConcept C153911025 @default.
- W3034506688 hasConcept C2778332815 @default.
- W3034506688 hasConcept C2778487026 @default.
- W3034506688 hasConcept C2780431358 @default.
- W3034506688 hasConcept C41008148 @default.
- W3034506688 hasConcept C53345823 @default.
- W3034506688 hasConcept C54355233 @default.
- W3034506688 hasConcept C86803240 @default.
- W3034506688 hasConcept C95444343 @default.
- W3034506688 hasConcept C97037327 @default.
- W3034506688 hasConceptScore W3034506688C102230213 @default.
- W3034506688 hasConceptScore W3034506688C104317684 @default.
- W3034506688 hasConceptScore W3034506688C111919701 @default.
- W3034506688 hasConceptScore W3034506688C122302759 @default.
- W3034506688 hasConceptScore W3034506688C150194340 @default.
- W3034506688 hasConceptScore W3034506688C153911025 @default.
- W3034506688 hasConceptScore W3034506688C2778332815 @default.
- W3034506688 hasConceptScore W3034506688C2778487026 @default.
- W3034506688 hasConceptScore W3034506688C2780431358 @default.
- W3034506688 hasConceptScore W3034506688C41008148 @default.
- W3034506688 hasConceptScore W3034506688C53345823 @default.