Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034517881> ?p ?o ?g. }
- W3034517881 endingPage "2421" @default.
- W3034517881 startingPage "2404" @default.
- W3034517881 abstract "Schizophrenia is a severe mental disorder that affects more than 1% of the population worldwide. Dopamine system dysfunction and alterations in glutamatergic neurotransmission are strongly implicated in the aetiology of schizophrenia. To date, antipsychotic drugs are the only available treatment for the symptoms of schizophrenia. These medications, which act as D2-receptor antagonist, adequately address the positive symptoms of the disease, but they fail to improve the negative symptoms and cognitive impairment. In schizophrenia, cognitive impairment is a core feature of the disorder. Therefore, the treatment of cognitive impairment and the other symptoms related to schizophrenia remains a significant unmet medical need. Currently, phosphodiesterases (PDEs) are considered the best drug target for the treatment of schizophrenia since many PDE subfamilies are abundant in the brain regions that are relevant to cognition. Thus, this review aims to illustrate the mechanism of PDEs in treating the symptoms of schizophrenia and summarises the encouraging results of PDE inhibitors as anti-schizophrenic drugs in preclinical and clinical studies." @default.
- W3034517881 created "2020-06-19" @default.
- W3034517881 creator A5022049131 @default.
- W3034517881 creator A5034512023 @default.
- W3034517881 date "2020-11-03" @default.
- W3034517881 modified "2023-10-18" @default.
- W3034517881 title "Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia" @default.
- W3034517881 cites W1498632927 @default.
- W3034517881 cites W1505831848 @default.
- W3034517881 cites W1544297197 @default.
- W3034517881 cites W1546190499 @default.
- W3034517881 cites W1548690558 @default.
- W3034517881 cites W1582714141 @default.
- W3034517881 cites W1608350875 @default.
- W3034517881 cites W1706609463 @default.
- W3034517881 cites W1793801688 @default.
- W3034517881 cites W1840737056 @default.
- W3034517881 cites W1857277871 @default.
- W3034517881 cites W1870077474 @default.
- W3034517881 cites W1927877903 @default.
- W3034517881 cites W1930926196 @default.
- W3034517881 cites W1945885879 @default.
- W3034517881 cites W1960607431 @default.
- W3034517881 cites W1960689142 @default.
- W3034517881 cites W1965030220 @default.
- W3034517881 cites W1965491450 @default.
- W3034517881 cites W1969056024 @default.
- W3034517881 cites W1970992086 @default.
- W3034517881 cites W1971797700 @default.
- W3034517881 cites W1972029787 @default.
- W3034517881 cites W1973931941 @default.
- W3034517881 cites W1975624776 @default.
- W3034517881 cites W1976624715 @default.
- W3034517881 cites W1977138162 @default.
- W3034517881 cites W1987865156 @default.
- W3034517881 cites W1988786263 @default.
- W3034517881 cites W1990270711 @default.
- W3034517881 cites W1997277329 @default.
- W3034517881 cites W2000073412 @default.
- W3034517881 cites W2004567605 @default.
- W3034517881 cites W2005828296 @default.
- W3034517881 cites W2007230852 @default.
- W3034517881 cites W2008020502 @default.
- W3034517881 cites W2009899857 @default.
- W3034517881 cites W2010407531 @default.
- W3034517881 cites W2012732096 @default.
- W3034517881 cites W2012801655 @default.
- W3034517881 cites W2019328464 @default.
- W3034517881 cites W2022764592 @default.
- W3034517881 cites W2022961682 @default.
- W3034517881 cites W2022991620 @default.
- W3034517881 cites W2023405690 @default.
- W3034517881 cites W2023503631 @default.
- W3034517881 cites W2023858737 @default.
- W3034517881 cites W2025038131 @default.
- W3034517881 cites W2032687148 @default.
- W3034517881 cites W2036351078 @default.
- W3034517881 cites W2037457092 @default.
- W3034517881 cites W2041937626 @default.
- W3034517881 cites W2043659733 @default.
- W3034517881 cites W2044157217 @default.
- W3034517881 cites W2046082567 @default.
- W3034517881 cites W2047073785 @default.
- W3034517881 cites W2047108643 @default.
- W3034517881 cites W2048099169 @default.
- W3034517881 cites W2049273984 @default.
- W3034517881 cites W2049374415 @default.
- W3034517881 cites W2052672755 @default.
- W3034517881 cites W2053070706 @default.
- W3034517881 cites W2054149684 @default.
- W3034517881 cites W2054484015 @default.
- W3034517881 cites W2055863987 @default.
- W3034517881 cites W2065365814 @default.
- W3034517881 cites W2067147530 @default.
- W3034517881 cites W2067738389 @default.
- W3034517881 cites W2068742279 @default.
- W3034517881 cites W2073618643 @default.
- W3034517881 cites W2074422008 @default.
- W3034517881 cites W2077117413 @default.
- W3034517881 cites W2079235686 @default.
- W3034517881 cites W2082625658 @default.
- W3034517881 cites W2085411745 @default.
- W3034517881 cites W2086302833 @default.
- W3034517881 cites W2088495343 @default.
- W3034517881 cites W2096271770 @default.
- W3034517881 cites W2096706827 @default.
- W3034517881 cites W2099188869 @default.
- W3034517881 cites W2099652807 @default.
- W3034517881 cites W2103553832 @default.
- W3034517881 cites W2104479866 @default.
- W3034517881 cites W2117445070 @default.
- W3034517881 cites W2118462346 @default.
- W3034517881 cites W2119511313 @default.
- W3034517881 cites W2122320022 @default.
- W3034517881 cites W2122946342 @default.
- W3034517881 cites W2124493262 @default.
- W3034517881 cites W2130270842 @default.
- W3034517881 cites W2130370960 @default.