Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034537466> ?p ?o ?g. }
- W3034537466 endingPage "649" @default.
- W3034537466 startingPage "649" @default.
- W3034537466 abstract "Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein involved in ribosome biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor-suppressor pathway among multiple other functions. Mutations in the corresponding gene cause a cytoplasmic dislocation of the NPM1 protein. These mutations are unique to acute myeloid leukemia (AML), a disease characterized by clonal expansion, impaired differentiation and the proliferation of myeloid cells in the bone marrow. Despite our improved understanding of NPM1 mutations and their consequences, the underlying leukemia pathogenesis is still unclear. Recent studies that focused on dysregulated gene expression in AML with mutated NPM1 have shed more light into these mechanisms. In this article, we review the current evidence on normal functions of NPM1 and aberrant functioning in AML, and highlight investigational strategies targeting these mutations." @default.
- W3034537466 created "2020-06-19" @default.
- W3034537466 creator A5059373442 @default.
- W3034537466 creator A5059600583 @default.
- W3034537466 creator A5080422730 @default.
- W3034537466 creator A5091492845 @default.
- W3034537466 date "2020-06-12" @default.
- W3034537466 modified "2023-10-12" @default.
- W3034537466 title "Nucleophosmin 1 Mutations in Acute Myeloid Leukemia" @default.
- W3034537466 cites W1485401273 @default.
- W3034537466 cites W1489666399 @default.
- W3034537466 cites W1554666790 @default.
- W3034537466 cites W1895606885 @default.
- W3034537466 cites W1965584494 @default.
- W3034537466 cites W1965912619 @default.
- W3034537466 cites W1967501957 @default.
- W3034537466 cites W1968776072 @default.
- W3034537466 cites W1969416692 @default.
- W3034537466 cites W1970954601 @default.
- W3034537466 cites W1971106148 @default.
- W3034537466 cites W1974798462 @default.
- W3034537466 cites W1974997430 @default.
- W3034537466 cites W1975967265 @default.
- W3034537466 cites W1977992135 @default.
- W3034537466 cites W1978926685 @default.
- W3034537466 cites W1979825473 @default.
- W3034537466 cites W1981449355 @default.
- W3034537466 cites W1985823023 @default.
- W3034537466 cites W1990225407 @default.
- W3034537466 cites W1990555927 @default.
- W3034537466 cites W1990739246 @default.
- W3034537466 cites W1990870968 @default.
- W3034537466 cites W1992826811 @default.
- W3034537466 cites W1997117872 @default.
- W3034537466 cites W2001866617 @default.
- W3034537466 cites W2003090098 @default.
- W3034537466 cites W2011458181 @default.
- W3034537466 cites W2014141207 @default.
- W3034537466 cites W2019845267 @default.
- W3034537466 cites W2030281466 @default.
- W3034537466 cites W2030497324 @default.
- W3034537466 cites W2030674478 @default.
- W3034537466 cites W2032054503 @default.
- W3034537466 cites W2035906662 @default.
- W3034537466 cites W2037257739 @default.
- W3034537466 cites W2038586807 @default.
- W3034537466 cites W2043216151 @default.
- W3034537466 cites W2043822218 @default.
- W3034537466 cites W2045087134 @default.
- W3034537466 cites W2045914521 @default.
- W3034537466 cites W2046857670 @default.
- W3034537466 cites W2048322426 @default.
- W3034537466 cites W2062674518 @default.
- W3034537466 cites W2068311105 @default.
- W3034537466 cites W2069849780 @default.
- W3034537466 cites W2071491707 @default.
- W3034537466 cites W2072383205 @default.
- W3034537466 cites W2073440691 @default.
- W3034537466 cites W2076031927 @default.
- W3034537466 cites W2078448904 @default.
- W3034537466 cites W2082627145 @default.
- W3034537466 cites W2082843075 @default.
- W3034537466 cites W2093827043 @default.
- W3034537466 cites W2098058376 @default.
- W3034537466 cites W2099454327 @default.
- W3034537466 cites W2113433319 @default.
- W3034537466 cites W2115707319 @default.
- W3034537466 cites W2115920391 @default.
- W3034537466 cites W2126816979 @default.
- W3034537466 cites W2131157723 @default.
- W3034537466 cites W2134168122 @default.
- W3034537466 cites W2135346203 @default.
- W3034537466 cites W2136249324 @default.
- W3034537466 cites W2138623699 @default.
- W3034537466 cites W2141702415 @default.
- W3034537466 cites W2142961359 @default.
- W3034537466 cites W2145415478 @default.
- W3034537466 cites W2148636018 @default.
- W3034537466 cites W2148965443 @default.
- W3034537466 cites W2149858388 @default.
- W3034537466 cites W2151718828 @default.
- W3034537466 cites W2152061559 @default.
- W3034537466 cites W2153556422 @default.
- W3034537466 cites W2154218976 @default.
- W3034537466 cites W2154227027 @default.
- W3034537466 cites W2162321261 @default.
- W3034537466 cites W2164725970 @default.
- W3034537466 cites W2170515966 @default.
- W3034537466 cites W2237124828 @default.
- W3034537466 cites W2276580523 @default.
- W3034537466 cites W2279856163 @default.
- W3034537466 cites W2300626718 @default.
- W3034537466 cites W2332345777 @default.
- W3034537466 cites W2339658711 @default.
- W3034537466 cites W2412183643 @default.
- W3034537466 cites W2419140434 @default.
- W3034537466 cites W2559537906 @default.
- W3034537466 cites W2571229748 @default.